Encapsulation of methylene blue in polyacrylamide nanoparticle platforms protects its photodynamic effectiveness
Encapsulation of methylene blue in polyacrylamide nanoparticle platforms protects its photodynamic effectiveness
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DOI：
10.1016/j.bbrc.2008.02.066
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发表时间：
2008-05-02
影响因子：
3.1
通讯作者：
Kopelman, Raoul
中科院分区：
文献类型：
--
作者：
Tang, Wei;Xu, Hao;Kopelman, Raoul
阻止亚甲蓝（MB），一种光敏剂，被血浆还原酶还原的能力将大大提高其在光动力学治疗（PDT）应用中的功效。我们已经开发了一种通过使用纳米颗粒平台（NPs）封装MB的PDT递送方法。基于30 nm聚丙烯酰胺的纳米颗粒为嵌入的MB提供保护，使其免受心肌黄酶的还原。此外，我们的数据显示基质保护的MB有效地诱导肿瘤细胞的光动力损伤。前所未有的结果证明了MB在封装在NP中时的显着体外光动力学有效性，这有望为MB在其体内和临床研究中开辟新的机会。爱思唯尔公司出版
The ability to prevent methylene blue (MB), a photosensitizer, from being reduced by plasma reductases will greatly improve its efficacy in photodynamic therapy (PDT) applications. We have developed a delivery approach for PDT by encapsulating MB using nanoparticle platforms (NPs). The 30-nm polyacrylamide-based NPs provide protection for the embedded MB against reduction by diaphorase enzymes. Furthermore, our data shows the matrix-protected MB efficiently induces photodynamic damage to tumor cells. The unprecedented results demonstrate the significant in vitro photodynamic effectiveness of MB when encapsulated within NPs, which promises to open new opportunities for MB in its in vivo and clinical studies. Published by Elsevier Inc.