AGING OF MODULATION OF HEART-RATE
AGING OF MODULATION OF HEART-RATE
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DOI：
10.1152/ajpheart.1987.253.4.h874
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发表时间：
1987-10-01
影响因子：
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通讯作者：
BENSON, H
中科院分区：
文献类型：
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作者：
SHANNON, DC;CARLEY, DW;BENSON, H
我们假设测量自主调节的心率波动可能提供生物衰老的定量探测。我们使用瞬时心率的功率谱分析，同时 33 名男性受试者将他们的呼吸与节拍器的呼吸频率匹配为 15 次/分钟。测量是在仰卧位和站立位进行的。总功率及其两个主要组成部分（高频功率和低频功率）在这两个位置上都随着年龄的增长而下降，但下降速度不同。仅在 9-28 岁受试者中，代表副交感神经介导的呼吸性窦性心律失常的高频功率在仰卧位时线性下降，斜率为 -0.796，与 P=0.0007 时的零显着不同。站立位高频功率的绝对值约为仰卧位高频功率的60%，差异有统计学意义（P=0.01）。代表β-肾上腺素能介导的心率波动的低频功率，特别是在站立位置时，线性下降到62岁(P＝0.0001)。与仰卧位相比，整个组站立时平均心率增加17.2次/分钟，舒张压增加8毫米汞柱。 30岁以上和30岁以下这些变化没有显着差异。我们得出的结论是，调节心率的两种主要机制的影响随着年龄的增长以显着不同的速度下降。
We postulated that measurements of autonomically mediated fluctuations in heart rate might provide a quantitative probe of biological aging. We used power spectrum analysis of instantaneous heart rate while 33 male subjects matched their breathing to a metronome at 15 breaths/min. Measurements were made in supine and standing position. Total power and its two major components, high- and low-frequency power, declined with age in both positions but at different rates. High-frequency power that represents parasympathetically mediated respiratory sinus arrhythmia declined linearly in supine position only in subjects 9-28 yr with a slope of -0.796, which was significantly different from zero at P=0.0007. The absolute value of high-frequency power in standing position was .apprx.60% of that in supine, a difference that was statistically significant (P = 0.01). Low-frequency power that represents .beta.-adrenergically mediated heart rate fluctuations, especially in standing position, declined linearly to 62 yr of age (P = 0.0001). Mean heart rate increased 17.2 beats/min, and diastolic blood pressure increased 8 mm Hg in the entire group in the standing compared with supine position. There were no significant differences in these changes above and below 30 yr of age. We conclude that the influence of the two major mechanisms that modulate heart rate decline at significantly different rates with aging.