Identification of MCP/CD46 analogue on bovine erythrocytes using the new monoclonal antibody IVA-520
Identification of MCP/CD46 analogue on bovine erythrocytes using the new monoclonal antibody IVA-520
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DOI：
10.1016/j.vetimm.2006.10.013
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发表时间：
2007-01-15
影响因子：
1.8
通讯作者：
Horovska, Lubica
中科院分区：
文献类型：
--
作者：
Antalikova, Jana;Simon, Michal;Horovska, Lubica
MCP/CD46是一种广泛分布于补体系统的C3b/C4b结合调节性糖蛋白，已在除红细胞外的所有人外周血细胞上发现。本文介绍了用新制备的单抗IVA-520鉴定包括红细胞在内的所有血细胞上的牛CD46。这种抗体与人和猪的细胞发生交叉反应。此外，IVA-520鉴定的分子在功能上表现为MCP分子，对因子I介导的牛补体C3因子的切割显示出辅因子活性。(C)2006爱思唯尔B.V.保留所有权利。
MCP/CD46 is a widely distributed C3b/C4b binding regulatory glycoprotein of the complement system that has been identified on all human peripheral blood cells except erythrocytes. In this paper, we describe the identification of bovine CD46 on all blood cells, including erythrocytes, with the newly prepared monoclonal antibody IVA-520. This antibody cross-reacts with human and pig cells. Furthermore, the molecule identified by IVA-520 functionally behaves as the MCP molecule, showing cofactor activity for the factor I-mediated cleavage of bovine C3 complement factor. (c) 2006 Elsevier B.V. All rights reserved.