Ventral neural patterning by Nkx homeobox genes:: Nkx6.1 controls somatic motor neuron and ventral interneuron fates
Ventral neural patterning by Nkx homeobox genes:: Nkx6.1 controls somatic motor neuron and ventral interneuron fates
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DOI：
10.1101/gad.820400
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发表时间：
2000-09-01
影响因子：
10.5
通讯作者：
Rubenstein, JLR
中科院分区：
文献类型：
--
作者：
Sander, M;Paydar, S;Rubenstein, JLR
越来越多的证据表明，音猬因子 (Shh) 信号通过 Nkx 类同源域蛋白调节脊椎动物中枢神经系统的腹侧神经元命运。我们检查了携带 Nkx6.1 靶向突变的小鼠的神经发生模式。这些突变体在祖细胞的身份和有丝分裂后神经元的命运方面表现出从背侧到腹侧的转变。在许多轴向水平上，V2 中间神经元和运动神经元的生成完全受阻，而 V1 神经元的生成域出现代偿性腹侧扩张，这证明了 Nkx6.1 在区域模式和神经元命运决定中的基本功能。
There is growing evidence that sonic hedgehog (Shh) signaling regulates ventral neuronal fate in the vertebrate central nervous system through Nkx-class homeodomain proteins. We have examined the patterns of neurogenesis in mice carrying a targeted mutation in Nkx6.1. These mutants show a dorsal-to-ventral switch in the identity of progenitors and in the fate of postmitotic neurons. At many axial levels there is a complete block in the generation of V2 interneurons and motor neurons and a compensatory ventral expansion in the domain of generation of V1 neurons, demonstrating the essential functions of Nkx6.1 in regional patterning and neuronal fate determination.