Direct photodegradation of carbamazepine followed by micellar electrokinetic chromatography and mass spectrometry
Direct photodegradation of carbamazepine followed by micellar electrokinetic chromatography and mass spectrometry
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DOI：
10.1016/j.watres.2010.10.037
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发表时间：
2011-01-01
期刊：
影响因子：
12.8
通讯作者：
Esteves, Valdemar I.
中科院分区：
文献类型：
--
作者：
Calisto, Vania;Domingues, M. Rosario M.;Esteves, Valdemar I.
卡马西平是一种广泛使用的精神药物，是环境中最常检测到的药物之一。为了更好地评估卡马西平在水基质中的环境持久性，本研究通过模拟太阳照射评估了pH和溶解氧对卡马西平直接光降解率的影响。为了跟踪降解和光产物的出现，开发了一种基于胶束电动色谱的方法，包括使用动态涂覆的毛细管柱。所建立的方法在卡马西平和光照射产物的分离中具有良好的重复性和效率。此外，通过电喷雾质谱（ESI-MS）鉴定了7种光降解产物，包括已知的在所有研究的pH和氧合水平下产生的致癌物质吖啶和一种新鉴定的光产物。本文对溶解氧对卡马西平光降解速率的影响有了新的认识。结果表明，酸性pH加上水中溶解氧的缺乏，导致了非常高的直接光降解率。在碱性pH下，溶解氧不干扰该过程，并且观察到极低的速率。在与环境相关的条件下，卡马西平在环境中的持续时间为4.5至25天。(C) 2010 Elsevier Ltd.版权所有。
Carbamazepine, a widely consumed psychotropic pharmaceutical, is one of the most commonly detected drugs in the environment. To better assess the environmental persistence of carbamazepine in aqueous matrices, the effect of pH and dissolved oxygen on the direct photodegradation rate of this pharmaceutical was evaluated in this study, using simulated solar irradiation. In order to follow the degradation and the emergence of photoproducts, a micellar electrokinetic chromatography based method was developed, consisting on the use of a dynamically coated capillary column. The developed methodology showed good repeatability and efficiency in the separation of carbamazepine and photoirradiation products. Also, seven photodegradation products were identified by electrospray mass spectrometry (ESI-MS), including the known carcinogenic acridine that was produced under all the pH and oxygenation levels studied and one newly identified photoproduct.This paper gives new insights into the role of dissolved oxygen on the photodegradation rate of carbamazepine. The results indicate that acidic pH, combined with the absence of dissolved oxygen in the aqueous matrix, results in very high direct photodegradation rates. At basic pH, dissolved oxygen does not interfere with the process and very low rates were observed. At environmentally relevant conditions, carbamazepine was shown to persist in the environment from 4.5 to 25 days. (C) 2010 Elsevier Ltd. All rights reserved.