Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2.
Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2.
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DOI：
10.1016/j.bbrc.2007.10.031
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发表时间：
2007-12
影响因子：
3.1
通讯作者：
Y. Okitsu;Shinichirou Takahashi;N. Minegishi;J. Kameoka;M. Kaku;Masayuki Yamamoto;Takeshi Sasaki;H. Harigae
中科院分区：
文献类型：
--
作者：
Y. Okitsu;Shinichirou Takahashi;N. Minegishi;J. Kameoka;M. Kaku;Masayuki Yamamoto;Takeshi Sasaki;H. Harigae
GATA-2是在多种细胞系的干细胞和祖细胞中表达的转录因子。在这项研究中，我们研究了GATA-2在脂肪细胞分化中的作用，脂肪细胞是造血微环境的主要组成部分。TBR343是一种前脂肪细胞基质细胞系，GATA-2的抑制导致脂肪细胞分化加速。相反，过表达GATA-2诱导脂肪细胞分化的阻力。此外，TBR343中GATA-2基因的调控元件与造血细胞中的相同。这些结果表明GATA-2通过调节脂肪细胞的分化来维持造血微环境。
GATA-2 is a transcription factor expressed in stem and progenitor cells of various cell lineages. In this study, we examined the role of GATA-2 in the differentiation of adipocytes, which are the main components of the microenvironment for hematopoiesis. Suppression of GATA-2 in TBR343, a preadipocytic stromal cell line, resulted in the acceleration of adipocyte differentiation. Conversely, overexpression of GATA-2 induced the resistance of adipocyte differentiation. In addition, regulatory elements of the GATA-2 gene in TBR343 are the same as those in hematopoietic cells. These results suggest that GATA-2 maintains a hematopoietic microenvironment by regulating the differentiation of adipocytes.