Antibody‐mediated demyelination in experimental allergic encephalomyelitis is independent of complement membrane attack complex formation
Antibody‐mediated demyelination in experimental allergic encephalomyelitis is independent of complement membrane attack complex formation
复制标题
实验性过敏性脑脊髓炎中抗体介导的脱髓鞘不依赖于补体膜攻击复合物的形成
DOI：
--
复制
发表时间：
1991
影响因子：
4.6
通讯作者：
C. Linington
中科院分区：
文献类型：
--
作者：
S. Piddlesden;Hans Lassmann;I. Laffafian;B. Morgan;C. Linington
The effects of decomplementation by cobra venom factor (CVF) on the pathogenesis of inflammation and demyelination in experimental allergic encephalomyelitis (EAE) and acute antibody‐mediated demyelinating EAE (ADEAE) have been quantified histologically and immunocytochcmically. In rats immunized with 50 μg of myelin basic protein in Freund's complete adjuvant containing 100μg heat‐killed Mycobacterium tuberculosis H37Ra, clinical signs of EAE were completely suppressed by two injections of CVF given 9 and 12 days post‐immunization. Suppression of clinical disease was associated with a dramatic reduction in peri‐vascular inflammation in the CNS. although immunohistochemical staining identified small numbers of infiltrating T cells and macrophages. In contrast, CVF treatment had no significant effect on the clinical severity of ADEAE and although C9 deposition within the CNS was virtually abolished, there was no statistically significant decrease in the extent of demyelination or inflammation. These observations indicate that in the absence of complement components C3 and C5 an antibody‐dependent cell‐mediated cytotoxic response plays an important role in the pathogenesis of antibody‐mediated demyelination. The major role of the complement cascade in EAE appears to be the generation of pro‐inflammatory factors that enhance the inflammatory response within the CNS in animals facing a mild encephalitogenic challenge.
眼镜蛇毒液因子：改进的纯化和生化表征方法。
影响因子：
2.2
作者：
Vogel,CW;Müller-Eberhard,HJ
通讯作者：
Müller-Eberhard,HJ
分离髓磷脂的补体激活：在缺乏髓磷脂特异性抗体的情况下激活经典途径。
DOI：
10.1073/pnas.79.10.3290
发表时间：
1982
影响因子：
11.1
作者：
Vanguri,P;Koski,CL;Silverman,B;Shin,ML
通讯作者：
Shin,ML
体外脱髓鞘研究：补体系统膜攻击成分的需要。
DOI：
--
发表时间：
1983
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Liu,WT;Vanguri,P;Shin,ML
通讯作者：
Shin,ML