The impact of a novel lung gross dissection protocol on intrapulmonary lymph node retrieval from lung cancer resection specimens.
The impact of a novel lung gross dissection protocol on intrapulmonary lymph node retrieval from lung cancer resection specimens.
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DOI：
10.1016/j.anndiagpath.2014.03.005
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发表时间：
2014-08
影响因子：
2
通讯作者：
Spencer, David
中科院分区：
文献类型：
--
作者：
Osarogiagbon, Raymond U.;Eke, Ransome;Sareen, Srishti;Leary, Cynthia;Coleman, LaShundra;Faris, Nicholas;Yu, Xinhua;Spencer, David
虽然彻底的病理淋巴结分期提供了最大的预后信息，患者有可能治愈的非小细胞肺癌，N1淋巴结转移经常被错过。我们用一种新的病理学大体解剖方案测试了纠正干预对肺内淋巴结取出的影响。对病理学家助理进行新型解剖方案培训前15个月和培训后15个月内的连续肺叶切除术或更大肺叶切除术标本进行回顾性审查。在引入新的解剖方案之前和之后检查了141个标本和121个标本。肺内淋巴结的中位数从2个增加到5个（p<0.0001），检测到的肺内淋巴结转移的第75 - 100百分位数范围从0 - 5增加到0 - 17（p= 0.0003）。在多变量分析中，切除范围、检查时间（干预前或干预后）和病理学N1（与N 0）状态与肺内淋巴结检查数量最密切相关。一种新的病理解剖协议是一种可行的和有效的手段，提高检索肺内淋巴结的检查。进一步的研究，以加强传播和实施这种新的病理解剖协议是必要的。
Although thorough pathologic nodal staging provides the greatest prognostic information in patients with potentially curable non-small cell lung cancer, N1 nodal metastasis is frequently missed. We tested the impact of corrective intervention with a novel pathology gross dissection protocol on intrapulmonary lymph node retrieval. Retrospective review of consecutive lobectomy, or greater, lung resection specimens over a period of 15 months before and 15 months after training Pathologist's Assistants on the novel dissection protocol. 141 specimens were examined before and 121 specimens after introduction of the novel dissection protocol. The median number of intrapulmonary lymph nodes retrieved increased from 2 to 5 (p<.0001), and the 75th – 100th percentile range of detected intrapulmonary lymph node metastasis increased from 0 – 5 to 0 – 17 (p=.0003). In multivariate analysis, the extent of resection, examination period (pre- or post-intervention), and pathologic N1 (vs. N0) status were most strongly associated with a higher number of intrapulmonary lymph nodes examined. A novel pathology dissection protocol is a feasible and effective means of improving the retrieval of intrapulmonary lymph nodes for examination. Further studies to enhance dissemination and implementation of this novel pathology dissection protocol are warranted.
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影响因子：
20.4
作者：
Osarogiagbon, Raymond U.;Yu, Xinhua
通讯作者：
Yu, Xinhua
影响因子：
20.4
作者：
Wei, Shenhai;Asamura, Hisao;Watanabe, Shun-ichi
通讯作者：
Watanabe, Shun-ichi
影响因子：
45.3
作者：
Pignon, Jean-Pierre;Tribodet, Helene;Le Chevalier, Thierry
通讯作者：
Le Chevalier, Thierry
影响因子：
6.2
作者：
Maeshima, Akiko Miyagi;Tsuta, Koji;Tsuda, Hitoshi
通讯作者：
Tsuda, Hitoshi
影响因子：
4.6
作者：
Osarogiagbon, Raymond U.;Ramirez, Robert A.;Robbins, Edward T.
通讯作者：
Robbins, Edward T.