DNA DOUBLE-STRAND BREAK REPAIR AND V(D)J RECOMBINATION - INVOLVEMENT OF DNA-PK
DNA DOUBLE-STRAND BREAK REPAIR AND V(D)J RECOMBINATION - INVOLVEMENT OF DNA-PK
复制标题
DOI：
10.1016/s0968-0004(00)89090-8
复制
发表时间：
1995-10-01
影响因子：
13.8
通讯作者：
JEGGO, PA
中科院分区：
文献类型：
--
作者：
JACKSON, SP;JEGGO, PA
涉及DNA双链断裂（DSB）的两个过程是电离辐射诱导的DNA损伤的修复和V（D）J重组，即在脊椎动物中产生抗原-受体多样性的基因组重排。最近的证据表明，由DNA末端激活的DNA依赖性蛋白激酶（DNA-PK）是DNA DSB修复和V（D）J重组机制的核心组成部分。
Two processes involving DNA double-strand breaks (DSBs) are the repair of DNA damage induced by ionizing radiation, and V(D)J recombination, the genomic rearrangement that creates antigen-receptor diversity in vertebrates. Recent evidence indicates that DNA-dependent protein kinase (DNA-PK), which is activated by DNA ends, is a central component of both the DNA DSB repair and V(D)J recombination machineries.