Pathophysiology of diabetic macular edema.
Pathophysiology of diabetic macular edema.
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DOI：
10.1097/iio.0b013e31819fd164
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发表时间：
2009-01-01
影响因子：
--
通讯作者：
Stewart, Jay M
中科院分区：
文献类型：
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作者：
Singh, Ajay;Stewart, Jay M
与糖尿病（DM）和糖尿病眼病相关的视力损害可能由DME（DME）、黄斑缺血、玻璃体出血或糖尿病牵引性视网膜脱离引起。在所有这些原因中，DME是该患者人群中视力丧失的最常见原因。来自威斯康星州糖尿病视网膜病变流行病学研究的数据表明，14年DME的发病率为26%。1 DME在临床上被视为视网膜增厚。早期治疗糖尿病视网膜病变研究进一步将其分类，以帮助医生做出关于其治疗的决策。在血管造影上，它被看作是在黄斑渗漏与染料池在长期黄斑水肿的地区。DME中视力丧失的原因是多因素的，包括光散射、受损的细胞间相互作用和视网膜中正常离子平衡的紊乱。病理生理学的研究着眼于由疾病引起或引起的详细功能障碍。本文将试图解释仍然难以捉摸的病理生理学DME。
Visual impairment associated with diabetes mellitus (DM) and diabetic eye disease may result from DME (DME), macular ischemia, vitreous hemorrhage, or diabetic tractional retinal detachment. Of all these causes, DME is the most common cause of vision loss in this patient population. Data from the Wisconsin Epidemiologic Study of Diabetic Retinopathy suggest that the 14-year incidence of DME is 26%. 1 DME is clinically seen as thickening of the retina. The Early Treatment Diabetic Retinopathy Study has further classified it to assist physicians in decision-making regarding its treatment. On angiography, it is seen as leakage in the macula with dye pooling in areas of longstanding macular edema. The reasons for visual loss in DME are multifactorial and include light scattering, impaired cell-to-cell interaction and disturbances of normal ionic balances in the retina. The study of pathophysiology looks at the detailed malfunctioning that arises from or-alternately-causes disease. This article will attempt to explain the still elusive pathophysiology of DME.