ASSOCIATIONS OF DIETARY PROTEIN INTAKE ON SUBSEQUENT DECLINE IN MUSCLE MASS AND PHYSICAL FUNCTIONS OVER FOUR YEARS IN AMBULANT OLDER CHINESE PEOPLE
ASSOCIATIONS OF DIETARY PROTEIN INTAKE ON SUBSEQUENT DECLINE IN MUSCLE MASS AND PHYSICAL FUNCTIONS OVER FOUR YEARS IN AMBULANT OLDER CHINESE PEOPLE
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DOI：
10.1007/s12603-013-0379-y
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发表时间：
2014-02-01
影响因子：
5.8
通讯作者：
Kwok, T.
中科院分区：
文献类型：
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作者：
Chan, R.;Leung, J.;Kwok, T.
目的：研究香港 65 岁及以上华人社区老年人的膳食蛋白质摄入量与身体机能指标和肌肉质量 4 年变化的关系。设计：前瞻性队列研究设计。地点：中华民国香港。参与者：共有 2,726 名 65 岁及以上的社区老年人（1411 名男性，1315 名女性）。测量：使用经过验证的食物频率调查问卷收集动物和植物蛋白质总摄入量的基线。计算以克/千克体重表示的相对蛋白质摄入量，并将其分为四分位数以进行数据分析。测量基线和 4 年身体表现指标（正常和窄 6 米步行速度和 6 米步行步长），并通过双能 X 射线吸收测定法评估四肢骨骼肌质量 (ASM) 相对于基线的 4 年变化。单变量分析确定年龄和性别是与身体表现指标或 ASM 变化相关的重要因素，因此对这些因素进行了调整以进行后续的协方差分析。结果：男性相对总蛋白质摄入量中位数为 1.3 克/公斤体重，女性为 1.1 克/公斤体重。调整年龄和性别后，相对总蛋白质摄入量和动物蛋白质摄入量与身体机能指标和 ASM 的变化无关。相比之下，相对植物蛋白摄入量最高四分位（>0.72克/公斤体重）的参与者在4年里减少的ASM明显少于相对植物蛋白摄入量最低四分位的参与者（
Objective: To examine the association of dietary protein intake with 4-year change in physical performance measures and muscle mass in Chinese community-dwelling older people aged 65 and older in Hong Kong. Design: Prospective cohort study design. Setting: Hong Kong, People's of Republic of China. Participants: There were 2,726 (1411 male, 1315 female) community-dwelling older people aged 65 and older. Measurements: Baseline total, animal and vegetable protein intakes were collected using a validated food frequency questionnaire. Relative protein intake expressed as g/kg body weight was calculated and divided into quartiles for data analysis. Baseline and 4-year physical performance measures (normal and narrow 6-meters walking speed and step length in a 6-meters walk) were measured and 4-year change in appendicular skeletal muscle mass (ASM) from baseline was assessed by dual-energy X-ray absorptiometry. Univariate analysis identified age and sex as significant factors associated with change in physical performance measures or ASM, thus adjustments for these factors were made for subsequent analysis of covariance. Results: Median relative total protein intake was 1.3 g/kg body weight in men and 1.1 g/kg body weight in women. after adjustment for age and sex, relative total protein intake and animal protein intake were not associated with change in physical performance measures and ASM. In contrast, participants in the highest quartile (>0.72 g/kg body weight) of relative vegetable protein intake lost significantly less ASM over 4-year than those in the lowest quartile of relative vegetable protein intake (