Synthesis of Biaryls through Nickel-Catalyzed Suzuki-Miyaura Coupling of Amides by Carbon-Nitrogen Bond Cleavage
Synthesis of Biaryls through Nickel-Catalyzed Suzuki-Miyaura Coupling of Amides by Carbon-Nitrogen Bond Cleavage
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DOI：
10.1002/anie.201601914
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发表时间：
2016-06-06
影响因子：
16.6
通讯作者：
Szostak, Michal
中科院分区：
文献类型：
--
作者：
Shi, Shicheng;Meng, Guangrong;Szostak, Michal
报道了首次Ni催化的Suzuki-Miyaura酰胺偶联反应，通过N-C酰胺键活化合成了广泛存在的联芳化合物。该反应容许两个偶联伙伴上的广泛的吸电子、电子中性和供电子取代基。该反应构成了镍催化生成芳基亲电试剂的第一个例子，具有广泛的有机金属反应的潜在应用。
The first Ni-catalyzed Suzuki-Miyaura coupling of amides for the synthesis of widely occurring biaryl compounds through N-C amide bond activation is reported. The reaction tolerates a wide range of electron-withdrawing, electron-neutral, and electron-donating substituents on both coupling partners. The reaction constitutes the first example of the Ni-catalyzed generation of aryl electrophiles from bench-stable amides with potential applications for a broad range of organometallic reactions.