The late stage of autophagy: cellular events and molecular regulation
The late stage of autophagy: cellular events and molecular regulation
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DOI：
10.1007/s13238-010-0121-z
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发表时间：
2010-10
期刊：
影响因子：
21.1
通讯作者：
Jingjing Tong;Xianghua Yan;Li Yu
中科院分区：
文献类型：
--
作者：
Jingjing Tong;Xianghua Yan;Li Yu
自噬是一种细胞内降解系统，将细胞质内容物递送到溶酶体进行降解。这是一个“自食”的过程，在细胞中起着“清洁房屋”的作用。自噬过程包括诱导、自噬体形成、溶酶体与自噬体融合、降解、降解产物外排转运和自噬性溶酶体重组等步骤。本文综述了自噬后期的细胞和分子调控，包括融合步骤后的细胞事件。
Autophagy is an intracellular degradation system that delivers cytoplasmic contents to the lysosome for degradation. It is a “self-eating” process and plays a “house-cleaner” role in cells. The complex process consists of several sequential steps—induction, autophagosome formation, fusion of lysosome and autophagosome, degradation, efflux transportation of degradation products, and autophagic lysosome reformation. In this review, the cellular and molecular regulations of late stage of autophagy, including cellular events after fusion step, are summarized.