Idiopathic Choroidal Neovascularization: Intraocular Inflammatory Cytokines and the Effect of Intravitreal Ranibizumab Treatment.
Idiopathic Choroidal Neovascularization: Intraocular Inflammatory Cytokines and the Effect of Intravitreal Ranibizumab Treatment.
复制标题
特发性脉络膜新生血管：眼内炎症细胞因子和玻璃体内雷珠单抗治疗的效果。
DOI：
10.1038/srep31880
复制
发表时间：
2016-08-25
影响因子：
4.6
通讯作者：
Yin J
中科院分区：
文献类型：
--
作者：
Yin H;Fang X;Ma J;Chen M;Yang Y;Guo S;Chen Z;Su Z;Feng L;Ye P;Wu F;Yin J
特发性脉络膜新生血管（ICNV）是一种主要影响50岁以下患者的疾病，可导致严重的视力丧失。脉络膜异常，尤其是脉络膜炎症，被认为与ICNV的病理生理有关。然而，ICNV的确切发病机制尚不清楚。本研究的目的是研究ICNV患者眼房水中27种炎性细胞因子的水平，并确定玻璃体内注射雷尼单抗（IVR）对细胞因子水平的影响。与对照组相比，ICNV患者IL-2、IL-10、IL-15、IL-17、基础FGF和GM-CSF水平显著升高。然而，在调整轴向长度后，ICNV患者中只有IL-17水平显著高于对照组。IL-10、IL-17、GM-CSF、VEGF水平与病变面积有显著相关性。术后患者的视敏度和视网膜中央厚度均有显著变化。除VEGF外，IVR还显著降低了IL-2、IL-10、基础FGF、IL-12水平，而IL-6水平显著升高。我们的研究结果表明，在ICNV的病因学中可能涉及il -17相关的炎症过程。
Idiopathic choroidal neovascularization (ICNV) is a disorder that primarily affecting patients younger than 50 years and can cause severe loss of vision. Choroidal abnormalities, especially choroidal inflammation, have been thought to be involved in the pathophysiology of ICNV. However, the exact pathogenesis of ICNV remains unclear. The aim of our study was investigate the levels of 27 inflammatory cytokines in the aqueous humor of eyes with ICNV and to determine the effect of intravitreal injection of ranibizumab (IVR) on cytokine levels. Significantly higher levels of IL-2, IL-10, IL-15, IL-17, basic FGF and GM-CSF were observed in patients with ICNV compared with controls. However, only IL-17 levels were significantly higher in patients with ICNV compared with controls after adjusting for axial length. Furthermore, there were significant correlations between the levels of IL-10, IL-17, GM-CSF and VEGF and the lesion area. Significant changes in visual acuity and central retinal thickness were observed after IVR. Besides VEGF, IVR also significantly reduced the levels of IL-2, IL-10, basic FGF and IL-12, however, the IL-6 levels were significantly increased. Our results suggest that there may be an involvement of IL-17-related inflammatory processes in the etiology of ICNV.