The Effect of Symbiotic Supplementation on Liver Enzymes, C-reactive Protein and Ultrasound Findings in Patients with Non-alcoholic Fatty Liver Disease: A Clinical Trial.
The Effect of Symbiotic Supplementation on Liver Enzymes, C-reactive Protein and Ultrasound Findings in Patients with Non-alcoholic Fatty Liver Disease: A Clinical Trial.
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DOI：
10.4103/2008-7802.178533
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发表时间：
2016
影响因子：
2.1
通讯作者：
Mohammadi V
中科院分区：
文献类型：
--
作者：
Asgharian A;Askari G;Esmailzade A;Feizi A;Mohammadi V
关于非酒精性脂肪性肝病（NAFLD）的日益流行，集中于各种策略来预防和管理似乎是必要的。本研究的目的是确定共生对NAFLD患者C反应蛋白（CRP）、肝酶和超声检查结果的影响。80例NAFLD患者入组了这项随机、双盲、安慰剂对照临床试验。参与者每天接受500毫克胶囊（含有七种益生菌和低聚果糖）或安慰剂胶囊形式的共生菌，持续8周。在基线和研究结束时评价超声分级、CRP和肝酶。在共生菌组中，超声分级与基线相比显著降低（P < 0.005），但共生菌补充与丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）水平的变化无关。在安慰剂组中，脂肪变性等级无显著变化，而ALT和AST水平显著升高（分别为P = 0.002，P = 0.02）。两组的CRP值保持不变。共生补充剂改善了NAFLD患者的脂肪变性，可能有助于NAFLD的管理或防止其进展。
Regarding to the growing prevalence of nonalcoholic fatty liver disease (NAFLD), concentrating on various strategies to its prevention and management seems necessary. The aim of this study was to determine the effects of symbiotic on C-reactive protein (CRP), liver enzymes, and ultrasound findings in patients with NAFLD. Eighty NAFLD patients were enrolled in this randomized, double-blind, placebo-controlled clinical trial. Participants received symbiotic in form of a 500 mg capsule (containing seven species of probiotic bacteria and fructooligosaccharides) or a placebo capsule daily for 8 weeks. Ultrasound grading, CRP, and liver enzymes were evaluated at the baseline and the end of the study. In the symbiotic group, ultrasound grade decreased significantly compared to baseline (P < 0.005) but symbiotic supplementation was not associated with changes in alanine aminotransferase (ALT) and aspartate transaminase (AST) levels. In the placebo group, there was no significant change in steatosis grade whereas ALT and AST levels were significantly increased (P = 0.002, P = 0.02, respectively). CRP values remained static in either group. Symbiotic supplementation improved steatosis in NAFLD patients and might be useful in the management of NAFLD or protective against its progression.