Recent developments in the CCP-EM software suite.
Recent developments in the CCP-EM software suite.
复制标题
DOI：
10.1107/s2059798317007859
复制
发表时间：
2017-06-01
期刊：
影响因子：
--
通讯作者：
Winn M
中科院分区：
文献类型：
--
作者：
Burnley T;Palmer CM;Winn M
概述了新的CCP-EM软件套件，包括支撑框架、当前功能和分发程序。该套件的第一个版本侧重于构建和改进原子模型。作为向低温电子显微镜社区提供计算支持的任务的一部分，电子冷冻显微镜合作计算项目(CCP-EM)开发了一个软件框架，使人们能够轻松访问一系列程序和实用程序。生成的软件套件通过将来自不同合作者的贡献封装在Python任务包装器中，然后通过用户友好的图形用户界面以及适合于脚本编写的命令行界面来访问这些贡献。该框架包括用于项目和数据管理的工具。对框架的设计进行了概述，并对不同层次的功能进行了概述。目前的CCP-EM套件在建立原子模型和将其改进为低温EM重建方面具有特别的优势，这一点将进行详细描述。
An overview is given of the new CCP-EM software suite, including the underpinning framework, the current functionality and the distribution procedure. This first version of the suite has a focus on building and refining atomic models. As part of its remit to provide computational support to the cryo-EM community, the Collaborative Computational Project for Electron cryo-Microscopy (CCP-EM) has produced a software framework which enables easy access to a range of programs and utilities. The resulting software suite incorporates contributions from different collaborators by encapsulating them in Python task wrappers, which are then made accessible via a user-friendly graphical user interface as well as a command-line interface suitable for scripting. The framework includes tools for project and data management. An overview of the design of the framework is given, together with a survey of the functionality at different levels. The current CCP-EM suite has particular strength in the building and refinement of atomic models into cryo-EM reconstructions, which is described in detail.