Downloadable computer models for renal replacement therapy.
Downloadable computer models for renal replacement therapy.
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用于肾脏替代治疗的可下载计算机模型。
DOI：
10.1038/sj.ki.5000196
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Meyer,TW
中科院分区：
文献类型：
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作者：
Walther,JL;Bartlett,DW;Chew,W;Robertson,CR;Hostetter,TH;Meyer,TW
数学模型可以预测肾脏替代治疗过程中的溶质清除率和溶质浓度。然而，目前大多数肾脏病学家不能使用这些模型，因为它们需要数学软件。在本报告中，我们描述了适用于Macintosh®计算机和运行Windows®的PC的常用软件程序Excel®上运行的对流和扩散溶质运移模型。已经创建了两个程序，可以从http://www.stanford.edu/~twmeyer/或http://dev.satellitehealth.com/research/journal.asp下载。第一种称为“阿迪斯博士清除率计算器”，根据输入计算清除率值，包括目标溶质的血流量Qb、血细胞比容、超滤率Qf、透析液流量Qd、反射系数σ和传质面积系数KoA，以及溶质与蛋白质结合时的游离分数。以图形方式显示沿人工肾长度沿着的溶质浓度曲线。第二个程序称为“Dr Coplon透析模拟器”，根据第一个程序获得的清除率值和其他输入值（包括每周治疗次数、治疗持续时间、溶质产生速率和分布体积）计算血浆溶质浓度。该程序计算时间平均溶质浓度，并通过一周的时间间隔提供溶质浓度曲线的图形显示。
Mathematical models can predict solute clearances and solute concentrations during renal replacement therapy. At present, however, most nephrologists cannot use these models because they require mathematical software. In this report, we describe models of solute transport by convection and diffusion adapted to run on the commonly available software program Excel® for Macintosh® computers and PCs running Windows®. Two programs have been created that can be downloaded from http://www.stanford.edu/~twmeyer/ or http://dev.satellitehealth.com/research/journal.asp. The first, called ‘Dr Addis Clearance Calculator’, calculates clearance values from inputs including the blood flowQb, the hematocrit, the ultrafiltration rateQf, the dialysate flow rateQd, the reflection coefficientσand the mass transfer area coefficientKoAfor the solute of interest, and the free fractionfif the solute is protein bound. Solute concentration profiles along the length of the artificial kidney are displayed graphically. The second program, called ‘Dr Coplon Dialysis Simulator’, calculates plasma solute concentrations from the clearance values obtained by the first program and from additional input values including the number of treatments per week, the duration of the treatments, and the solute's production rate and volumes of distribution. The program calculates the time-averaged solute concentration and provides a graphic display of the solute concentration profile through a week-long interval.