In vitro corrosion and biocompatibility of binary magnesium alloys
In vitro corrosion and biocompatibility of binary magnesium alloys
复制标题
二元镁合金的体外腐蚀与生物相容性
DOI：
10.1016/j.biomaterials.2008.10.021
复制
发表时间：
2009-02-01
期刊：
影响因子：
14
通讯作者：
Xi, Tingfei
中科院分区：
文献类型：
--
作者：
Gu, Xuenan;Zheng, Yufeng;Xi, Tingfei
作为生物可吸收材料，镁合金在体内可完全降解，其生物腐蚀产物对周围组织无害。考虑到它们的细胞毒性和血液相容性，仔细选择合金元素是至关重要的。在本研究中，将Al、Ag、In、Mn、Si、Sn、Y、Zn和Zr等9种合金元素分别添加到镁中，制备了二元Mg-1X（wt.%）合金。合金.纯镁用作对照。通过扫描电镜、X射线衍射、拉伸试验、浸泡试验、电化学腐蚀试验、细胞培养和血小板粘附试验等方法，对材料的力学性能、腐蚀性能和体外生物相容性（细胞毒性和血液相容性）进行了评价。结果表明，合金元素的加入会影响镁合金的强度和耐蚀性。细胞毒性试验表明，Mg-1Al、Mg-1 Sn和Mg-1 Zn合金浸提液对成纤维细胞（L-929和NIH 3 T3）和成骨细胞（MC 3 T3-E1）的细胞活力无显著降低：Mg-1A 1和Mg-1 Zn合金浸提液对血管相关细胞、ECV 304和VSMC的活力无不良影响。结果发现，与纯镁对照相比，所有Mg-1X合金化后溶血和粘附血小板的量减少。讨论了腐蚀产物与生物相容性之间的关系，并提出了与骨和血管相关的生物医学应用中合适的合金元素。(C)2008爱思唯尔有限公司保留所有权利。
As bioabsorbable materials, magnesium alloys are expected to be totally degraded in the body and their biocorrosion products not deleterious to the surrounding tissues. it's critical that the alloying elements are carefully selected in consideration of their cytotoxicity and hemocompatibility. In the present study, nine alloying elements Al, Ag, In, Mn, Si, Sn, Y, Zn and Zr were added into magnesium individually to fabricate binary Mg-1X (wt.%) alloys. Pure magnesium was used as control. Their mechanical properties, corrosion properties and in vitro biocompatibilities (cytotoxicity and hemocompatibility) were evaluated by SEM, XRD, tensile test, immersion test, electrochemical corrosion test, cell culture and platelet adhesion test. The results showed that the addition of alloying elements could influence the strength and corrosion resistance of Mg. The cytotoxicity tests indicated that Mg-1Al, Mg-1Sn and Mg-1Zn alloy extracts showed no significant reduced cell viability to fibroblasts (L-929 and NIH3T3) and osteoblasts (MC3T3-E1): Mg-1A1 and Mg-1Zn alloy extracts indicated no negative effect on viabilities of blood vessel related cells, ECV304 and VSMC. It was found that hemolysis and the amount of adhered platelets decreased after alloying for all Mg-1X alloys as compared to the pure magnesium control. The relationship between the corrosion products and the in vitro biocompatibility had been discussed and the suitable alloying elements for the biomedical applications associated with bone and blood vessel had been proposed. (C) 2008 Elsevier Ltd. All rights reserved.