Circular Logic: Nonribosomal Peptide-like Macrocyclization with a Ribosomal Peptide Catalyst
Circular Logic: Nonribosomal Peptide-like Macrocyclization with a Ribosomal Peptide Catalyst
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DOI：
10.1021/ja1067806
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发表时间：
2010-11-10
影响因子：
15
通讯作者：
Schmidt, Eric W.
中科院分区：
文献类型：
--
作者：
McIntosh, John A.;Robertson, Charles R.;Schmidt, Eric W.
核糖体肽生物合成的蛋白酶大环化多种底物，包括那些类似于非核糖体肽和杂合聚酮肽产物的底物。所提出的机制类似于硫酯酶催化的化学反应，但底物是酰胺键而不是硫酯。
A protease from ribosomal peptide biosynthesis macrocyclizes diverse substrates, including those resembling nonribosomal peptide and hybrid polyketide-peptide products. The proposed mechanism is analogous to thioesterase-catalyzed chemistry, but the substrates are amide bonds rather than thioesters.