Time-dependent central compensatory mechanisms of finger dexterity after spinal cord injury
Time-dependent central compensatory mechanisms of finger dexterity after spinal cord injury
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DOI：
10.1126/science.1147243
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发表时间：
2007-11-16
期刊：
影响因子：
56.9
通讯作者：
Isa, Tadashi
中科院分区：
文献类型：
--
作者：
Nishimura, Yukio;Onoe, Hirotaka;Isa, Tadashi
横断脊髓颈中段皮质-运动神经元直接通路导致猕猴手指运动的一过性损伤。手指的灵活度在几个月内恢复。综合脑成像和可逆的运动皮质区药理学失活表明，恢复涉及双侧初级运动皮质在恢复早期和更广泛的区域对侧初级运动皮质和双侧运动前皮质在恢复后期。这些额叶运动相关区域激活模式的变化代表了脊髓损伤后功能代偿的适应性策略。
Transection of the direct cortico-motoneuronal pathway at the mid-cervical segment of the spinal cord in the macaque monkey results in a transient impairment of finger movements. Finger dexterity recovers within a few months. Combined brain imaging and reversible pharmacological inactivation of motor cortical regions suggest that the recovery involves the bilateral primary motor cortex during the early recovery stage and more extensive regions of the contralesional primary motor cortex and bilateral premotor cortex during the late recovery stage. These changes in the activation pattern of frontal motor-related areas represent an adaptive strategy for functional compensation after spinal cord injury.