Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE
Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE
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DOI：
10.1126/science.aba0864
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发表时间：
2020-11-20
期刊：
影响因子：
56.9
通讯作者：
Ginhoux, Florent
中科院分区：
文献类型：
--
作者：
Msallam, Rasha;Balla, Jozef;Ginhoux, Florent
肥大细胞 (MC) 是过敏反应中的中心效应细胞，通常由免疫球蛋白 E (IgE) 介导。过敏通常在很小的时候就开始出现，并且在胎儿中均可检测到 MC 和 IgE。然而，胎儿 IgE 的起源以及胎儿 MC 是否可以响应 IgE 依赖性激活而脱颗粒目前尚不清楚。在这里，我们发现人类和小鼠胎儿 MC 在怀孕期间表型成熟，并且可以被母体 IgE 致敏。 IgE 依赖于胎儿新生儿 Fc 受体 (FcRN) 穿过胎盘，并使胎儿 MC 敏感，进行过敏原特异性脱颗粒。被动和主动的产前致敏都会赋予过敏原敏感性，导致产后第一次接触过敏原后出现皮肤和呼吸道炎症。我们报告了 MC 在发育中胎儿中的作用，并证明胎儿 MC 可能有助于过敏性疾病的抗原特异性垂直传播。
Mast cells (MCs) are central effector cells in allergic reactions that are often mediated by immunoglobulin E (IgE). Allergies commonly start at an early age, and both MCs and IgE are detectable in fetuses. However, the origin of fetal IgE and whether fetal MCs can degranulate in response to IgE-dependent activation are presently unknown. Here, we show that human and mouse fetal MCs phenotypically mature through pregnancy and can be sensitized by maternal IgE. IgE crossed the placenta, dependent on the fetal neonatal Fc receptor (FcRN), and sensitized fetal MCs for allergenspecific degranulation. Both passive and active prenatal sensitization conferred allergen sensitivity, resulting in postnatal skin and airway inflammation after the first allergen encounter. We report a role for MCs within the developing fetus and demonstrate that fetal MCs may contribute to antigen-specific vertical transmission of allergic disease.