The Ras/cAMP/PKA signaling pathway and virulence in Candida albicans
The Ras/cAMP/PKA signaling pathway and virulence in Candida albicans
复制标题
DOI：
10.2217/fmb.09.106
复制
发表时间：
2009-12-01
影响因子：
3.1
通讯作者：
Sundstrom, Paula
中科院分区：
文献类型：
--
作者：
Hogan, Deborah A.;Sundstrom, Paula
念珠菌病是真菌感染的最常见原因，其中大多数是由白色念珠菌引起的。C.白色念珠菌包括感染各种粘膜和表皮表面以及通过血流传播到内部器官的能力，在严重免疫抑制的情况下可能导致系统衰竭。宿主体内的许多环境生态位都可能被C.白念珠菌通过调节基因表达模式，同时改变酵母和菌丝生长形式之间的形态。Ras/cAMP/PKA信号通路因其在促进菌丝生长中的作用和在毒力方面的重要性而引起特别的关注。在这里，我们提出了一个概述的组成部分的途径和它们的功能，途径如何可能被激活在人类宿主和最近更新的作用Ras/cAMP/PKA信号在毒力。
Candidiasis is the most common cause of fungal infections, and the majority of these are caused by Condida albicans. The protean pathogenic potential of C. albicans includes the capacity to infect diverse mucosal and epidermal surfaces as well as to disseminate via the bloodstream to internal organs, potentially causing system failure in cases of severe immunosuppression. Many environmental niches in the host may be invaded by C. albicans through modulation of gene expression patterns while changing morphology between yeast and hyphal growth forms. The Ras/cAMP/PKA signaling pathway has attracted particular attention for its role in promoting hyphal growth and because of its importance in virulence. Here, we present an overview of the components of the pathway and their functions, how the pathway may be activated in human hosts and recent updates regarding the role of Ras/cAMP/PKA signaling in virulence.