The role of adiponectin in metabolic and vascular disease: a review
The role of adiponectin in metabolic and vascular disease: a review
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DOI：
10.2379/cnp75026
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发表时间：
2011-01-01
影响因子：
1.1
通讯作者：
Falkner, B.
中科院分区：
文献类型：
--
作者：
Cui, J.;Panse, S.;Falkner, B.
脂联素是一种由脂肪组织分泌的蛋白质。与脂肪组织产生的其他脂肪细胞因子不同，脂联素似乎具有抗炎、抗糖尿病和抗动脉粥样硬化的特性。虽然只由脂肪组织分泌，但血浆脂联素水平通常与总脂肪质量呈负相关；瘦人的血浆脂联素水平较高，肥胖者的脂联素水平较低。胰岛素抵抗患者的血浆脂联素浓度低于胰岛素敏感患者；糖尿病患者的血浆脂联素浓度低于非糖尿病患者。据报道，血浆脂联素水平与高血压(HTN)、血压水平和蛋白尿之间存在类似的负相关关系。然而，在慢性肾脏疾病(CKD)中，血浆脂联素浓度显著升高已被描述。终末期肾病患者血浆脂联素水平显著升高，肾移植后血浆脂联素水平降低。考虑到血浆脂联素与肾功能呈负相关，脂联素在慢性肾脏病患者中的心血管保护作用仍存在争议。CKD患者体内不同循环部分脂联素的分布和功能有待进一步研究，以确定脂联素是否为CKD患者有用的生物标志物。
Adiponectin is a protein secreted by adipose tissue. Unlike other adipocytokines produced by adipose tissue, adiponectin appears to have anti-inflammatory, anti-diabetic, and anti-atherogenic properties. Although secreted solely by adipose tissue, plasma levels of adiponectin are generally negatively related to total adipose mass; with higher plasma adiponectin levels in lean individuals and lower adiponectin levels in obese individuals. Plasma concentrations of adiponectin are lower in patients with insulin resistance compared to insulin sensitive patients; and lower in patients with diabetes compared to non-diabetics. A similar inverse relationship of plasma adiponectin level has been reported with hypertension (HTN), blood pressure level, and albuminuria. However, in chronic kidney disease (CKD) marked elevations in plasma adiponectin concentrations have been described. Plasma adiponectin levels are markedly elevated among patients with end-stage renal disease and are lower following kidney transplantation. Considering the inverse relationship of plasma adiponectin with renal function, the cardiovascular protective role of adiponectin in patients with CKD remains controversial. Further research on the distribution and function of different circulating fractions of adiponectin in patients with CKD will be needed in order to determine if adiponectin is a useful biomarker in patients with CKD.