A parallel combinatorial approach to locating homochiral Lewis acid catalysts for the asymmetric aza-Diels-Alder reaction of an imino dienophile.
A parallel combinatorial approach to locating homochiral Lewis acid catalysts for the asymmetric aza-Diels-Alder reaction of an imino dienophile.
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DOI：
10.1016/s0040-4039(98)01947-9
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发表时间：
1998-11-26
影响因子：
1.8
通讯作者：
Whiting, A
中科院分区：
文献类型：
--
作者：
Bromidge, S;Wilson, PC;Whiting, A
已开发出新的催化不对称路易斯酸，用于乙醛酸甲酯和对茴香胺衍生的亚胺与达尼塞夫斯基二烯的氮杂-狄尔斯-阿尔德反应。该催化剂采用平行组合方法开发，使用乙腈中的 (1S, 2S)-1,2-二苯基乙二胺和碘化镁，其 e.e. 达到 97%。 (C) 1998 Elsevier Science Ltd. 保留所有权利。
New catalytic asymmetric Lewis acids have been developed for the aza-Diels-Alder reaction of a methyl glyoxalate and p-anisidine derived imine with Danishefsky's diene. The catalysts were developed using parallel combinatorial methods with the highest e.e, being 97 % using (1S, 2S)-1,2-diphenylthylenediamine and magnesium iodide in acetanitrile. (C) 1998 Elsevier Science Ltd. All rights reserved.