Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas
Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas
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DOI：
10.1038/ng1013
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发表时间：
2002-11-01
期刊：
影响因子：
30.8
通讯作者：
Eng, C
中科院分区：
文献类型：
--
作者：
Kurose, K;Gilley, K;Eng, C
我们最近的研究表明，在原发性浸润性乳腺癌的间质和上皮细胞中，包括10 q23，17 p13-p15和16 q24的特异性标记物的杂合性丢失可能发生。在这里，我们证明了乳腺肿瘤上皮和间质中TP 53（编码肿瘤蛋白p53）和PTEN（编码磷酸盐和张力蛋白同源物）的高频率体细胞突变。TP 53和PTEN中的突变在任一区室中是相互排斥的。相比之下，WFDC 1（16 q24，编码WAP四-二硫键核心结构域1）的突变在基质中发生频率较低。
We have recently shown that loss of heterozygosity of specific markers, including those at 10q23, 17p13-p15 and 16q24, can occur in the stromal and epithelial compartments of primary invasive breast carcinomas. Here, we demonstrate high frequencies of somatic mutations in TP53 (encoding tumor protein p53) and PTEN (encoding phosphate and tensin homolog) in breast neoplastic epithelium and stroma. Mutations in TP53 and PTEN are mutually exclusive in either compartment. In contrast, mutations in WFDC1 (16q24, encoding WAP four-disulfide core domain 1) occur with low frequency in the stroma.