Cycloplegic effect of 0.5% tropicamide and 0.5% phenylephrine mixed eye drops: Objective assessment in japanese schoolchildren with myopia
Cycloplegic effect of 0.5% tropicamide and 0.5% phenylephrine mixed eye drops: Objective assessment in japanese schoolchildren with myopia
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DOI：
10.1007/s10384-006-0400-7
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发表时间：
2007-03-01
影响因子：
2.4
通讯作者：
Ohtsuki, Hiroshi
中科院分区：
文献类型：
--
作者：
Hamasaki, Ichiro;Hasebe, Satoshi;Ohtsuki, Hiroshi
目的：评价0.5%托吡卡胺和0.5%苯肾上腺素混合滴眼液治疗儿童近视的睫状肌麻痹效果，并探讨其疗效与临床特征的关系。方法：近视儿童81例，年龄平均+/-SD，11.0±-1.5岁；平均等效球镜屈光度-4.27+/-1.41D；-1.57~-8.66D。每只眼滴入一滴美多丽-P两次，两次之间间隔5分钟。在第二次下降25分钟后，用开放式自动屈光计测量调节反应，同时通过双目观察位于33厘米远的马耳他十字来鼓励受试者调节。屈光读数与马耳他十字500 cm屈光读数的差值被认为是残余调节(RA)。结果：平均RA为0.21+/-0.29D(范围-0.31~0.99D)。右眼与左眼之间、年龄与年龄之间、性别与RA之间均无相关性，但RA与屈光度呈弱相关(r=0.274，P=0.019)。类风湿性眼病的受试者间差异主要可以用重复性(+/-0.71D)来解释。结论：混合眼药水的大小并不显著，表明混合眼药水是一种可以接受的有用的睫状肌麻痹药物，适用于有广泛近视屈光不正的日本学龄儿童。
Purpose: To evaluate the cycloplegic effect of mixed eye drops containing 0.5% tropicamide and 0.5% phenylephrine in myopic children, and to determine whether their efficacy was associated with their clinical characteristics.Methods: Eighty-one myopic children (age, mean +/- SD, 11.0 +/- 1.5 years; mean spherical equivalent refractive error, -4.27 +/- 1.41 D; range, -1.57 to -8.66 D) were recruited. One drop of Mydrin-P was administered to each eye twice, with an interval of 5 min between. Twenty-five minutes after the second drop, accommodative responses were measured with an open-view autorefractometer, while the subject was encouraged to accommodate by binocularly looking at a Maltese cross located at a distance of 33 cm. The difference between the refractive reading and that obtained with a Maltese cross at 500 cm was regarded as residual accommodation (RA). The repeatability of this measurement was also evaluated.Results: The mean RA was 0.21 +/- 0.29 D (range, -0.31 to 0.99 D). There was no association in RA between the right and left eyes, between RA and age, or between RA and sex, but RA was weakly correlated with refractive error (r = 0.274, P = 0.019). The intersubject difference found in RA can be explained mostly by the extent of repeatability (+/- 0.71 D).Conclusion: The insignificant magnitude of RA indicated that the mixed eye drop is an acceptable and useful cycloplegic agent in Japanese schoolchildren with a wide range of myopic refractive errors.