3-D high-strength glass-ceramic scaffolds containing fluoroapatite for load-bearing bone portions replacement
3-D high-strength glass-ceramic scaffolds containing fluoroapatite for load-bearing bone portions replacement
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DOI：
10.1016/j.msec.2009.04.002
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发表时间：
2009-08-01
影响因子：
7.9
通讯作者：
Vitale-Brovarone, Chiara
中科院分区：
文献类型：
--
作者：
Baino, Francesco;Verne, Enrica;Vitale-Brovarone, Chiara
本研究旨在制备骨组织工程用三维微晶玻璃支架，并对其结构、力学性能和生物活性进行研究。支架材料是通过熔融淬火路线合成的含氟磷灰石的玻璃陶瓷。将玻璃陶瓷粉末与作为成孔剂的聚乙烯颗粒混合;将该共混物压制以获得“绿色”压坯，该压坯经热处理以除去有机相并烧结无机相。通过X射线衍射、扫描电镜、密度测量和毛细管力测试对支架的结构和形态进行了表征。通过挤压实验考察支架的力学性能。通过将支架在模拟体液中浸泡不同的时间范围并通过分析样品表面上发生的修饰来评估体外生物活性。支架具有互连的大孔结构，孔隙高达50%体积，并且它们表现出正交各向异性的机械行为和远高于20 MPa的强度。此外，体外试验证明了该材料的优异生物活性。因此，所制备的支架可用于骨重建手术中作为有效的承重移植物，这归功于它们易于剪裁、生物活性和高机械强度。(C)2009爱思唯尔有限公司版权所有。
This study aimed to fabricate and investigate the structure, mechanical properties and bioactivity of three-dimensional (3-D) glass-ceramic scaffolds for bone tissue engineering. The scaffold material was a fluoroapatite-containing glass-ceramic synthesized by a melting-quenching route. Glass-ceramic powders were mixed with polyethylene particles acting as pore formers; the blend was pressed to obtain "green" compacts that were thermally treated to remove the organic phase and to sinter the inorganic one. The structure and morphology of the resulting scaffolds were characterized by X-ray diffraction, scanning electron microscopy, density measurements and capillarity tests. Crushing tests were carried out to investigate the mechanical properties of the scaffolds. The in vitro bioactivity was assessed by soaking the scaffolds in simulated body fluid for different time frames and by analyzing the modifications that occurred on the sample surface. The scaffolds had an interconnected macroporous structure with pores up to 50% vol. and they showed an orthotropic mechanical behaviour and strength well above 20 MPa. In addition, in vitro tests put into evidence the excellent bioactivity of the material. Therefore, the prepared scaffolds can be used in bone reconstructive surgery as effective load-bearing grafts thanks to their ease of tailoring, bioactive properties and high mechanical strength. (C) 2009 Elsevier B.V. All rights reserved.