Generalized pustular figurate erythema: A newly delineated severe cutaneous drug reaction linked with hydroxychloroquine
Generalized pustular figurate erythema: A newly delineated severe cutaneous drug reaction linked with hydroxychloroquine
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DOI：
10.1111/dth.13380
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发表时间：
2020-04-16
影响因子：
3.6
通讯作者：
Janniger, Camila K.
中科院分区：
文献类型：
--
作者：
Schwartz, Robert A.;Janniger, Camila K.
据报道，摄入羟氯喹会导致严重的皮肤药物反应，类似于急性全身性发疹性脓疱病。其特点是潜伏期较长、形态更加多样（最初为荨麻疹，后来为靶状和弓形斑块）、治疗不耐受以及持续时间较长。鉴于羟氯喹据报道对 2019 年冠状病毒病患者有益，预计其使用量将激增，因此对该实体的具体认识至关重要。我们将其描述为全身性脓疱状红斑。
A severe cutaneous drug reaction resembling acute generalized exanthematous pustulosis resulting from ingestion of hydroxychloroquine has been documented. It is distinguishable by its longer incubation period, more varied morphology with initially urticarial and later targetoid and arcuate plaques, recalcitrance to therapy and longer duration. Given the anticipated surge in the use of hydroxychloroquine due to its reported benefits in those with coronavirus disease 2019, specific recognition of this entity is pivotal. We delineate it as generalized pustular figurate erythema.