Pathological and immunohistochemical features of subdural histiocytic sarcomas in 15 dogs
Pathological and immunohistochemical features of subdural histiocytic sarcomas in 15 dogs
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DOI：
10.1177/104063871102300123
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发表时间：
2011-01-01
影响因子：
1.5
通讯作者：
Nakayama, Hiroyuki
中科院分区：
文献类型：
--
作者：
Ide, Tetsuya;Uchida, Kazuyuki;Nakayama, Hiroyuki
对15只狗（平均年龄：7.8岁）的硬膜下组织细胞肉瘤进行了组织病理学检查。在这15只狗中，有明显的品种优势（彭布罗克威尔士柯基犬，47%），但没有性别偏好。在大脑（12例）和脊髓（1例）中发现局灶性孤立硬膜下肿块，在脑轻脑膜（2例）中发现弥漫性浸润性病变。所有肿瘤病变都有共同的组织学特征，即多形性组织细胞增生并伴有多种炎症反应。肿瘤细胞常可见多核巨细胞、吞噬和非典型有丝分裂象。除了2例局灶性和2例弥散性组织细胞肉瘤中的肿瘤细胞外，本病例中大多数多形性肿瘤细胞对单核细胞、组织细胞或两种标记物，如人白细胞抗原(HLA)-DR、离子钙结合适配器分子1 （Iba1）、分化簇（CD）163和CD204均呈免疫阳性。研究结果表明，细胞起源、分子表达或两者的差异是犬硬膜下组织细胞肉瘤分布模式的原因。
Subdural histiocytic sarcomas from 15 dogs (mean age: 7.8 years) were histopathologically examined. Among the 15 dogs, there was a marked breed predominance (toward Pembroke Welsh Corgi dogs, 47%), but no gender predilection. Focal solitary subdural masses were detected in the cerebrum (12 cases) and spinal cord (1 case), whereas diffuse infiltrative lesions were observed in the cerebral leptomeninges in 2 cases. All neoplastic lesions had common histological features characterized by the proliferation of pleomorphic histiocytic cells combined with various inflammatory reactions. Multinucleated giant cells, phagocytosis, and atypical mitotic figures in the neoplastic cells were commonly observed. Most of the pleomorphic neoplastic cells in the present cases were immunopositive for monocytic, histiocytic, or both markers, such as human leukocyte antigen (HLA)-DR, ionized calcium-binding adaptor molecule 1 (Iba1), cluster of differentiation (CD)163, and CD204, except for the neoplastic cells in 2 focal and 2 diffuse histiocytic sarcomas. The findings suggest that differences in cell origin, molecular expression, or both patterns are responsible for the distribution patterns of canine subdural histiocytic sarcomas.