A new method to monitor visual field defects caused by photoreceptor degeneration by quantitative optical coherence tomography
A new method to monitor visual field defects caused by photoreceptor degeneration by quantitative optical coherence tomography
复制标题
DOI：
10.1167/iovs.08-2003
复制
发表时间：
2008-08-01
影响因子：
4.4
通讯作者：
Barthelmes, Daniel
中科院分区：
文献类型：
--
作者：
Fischer, M. Dominik;Fleischhauer, Johannes C.;Barthelmes, Daniel
目的.目的探讨视网膜色素变性（RP）患者的Goldman动态视野检查视野（VF）的大小与光学相干断层扫描（OCT）图像中可见的光感受器（IOS）内外段之间高反射层的可见程度之间的关系。在一项回顾性设计的横断面研究中，18例RP患者的18只眼使用测试目标I4e进行OCT和Goldmann视野检查，并与18例对照受试者的18只眼进行比较。定量分析Stratus OCT图像（Carl Zeiss Meditec，AG，上科亨，德国）原始扫描数据的A扫描，以确定OCT图像中IOS之间的高反射层产生的信号是否存在。从中央凹开始，测量可检测到该信号的距离。通过测量中心点到等线I4e的距离来分析视野。OCT和视野数据以顺时针方式每30分钟分析一次，并将相应的测量结果进行相关性分析。在相应的排列中，中心点到等线I4e的距离与可检测到来自IOS的高反射信号的距离显著相关（r = 0.75，P < 0.0001）。VF中的距离越大，OCT中测量的距离越大。作者假设，IOS之间的高反射层所发出的视网膜结构对于视觉和感光功能至关重要。进一步的研究是必要的，以确定这是否可能是一个有用的客观标志物与RP患者的视网膜变性的进展。
PURPOSE. To correlate the dimension of the visual field (VF) tested by Goldman kinetic perimetry with the extent of visibility of the highly reflective layer between inner and outer segments of photoreceptors (IOS) seen in optical coherence tomography (OCT) images in patients with retinitis pigmentosa (RP).METHODS. In a retrospectively designed cross-sectional study, 18 eyes of 18 patients with RP were examined with OCT and Goldmann perimetry using test target I4e and compared with 18 eyes of 18 control subjects. A-scans of raw scan data of Stratus OCT images (Carl Zeiss Meditec, AG, Oberkochen, Germany) were quantitatively analyzed for the presence of the signal generated by the highly reflective layer between the IOS in OCT images. Starting in the fovea, the distance to which this signal was detectable was measured. Visual fields were analyzed by measuring the distance from the center point to isopter I4e. OCT and visual field data were analyzed in a clockwise fashion every 30, and corresponding measures were correlated.RESULTS. In corresponding alignments, the distance from the center point to isopter I4e and the distance to which the highly reflective signal from the IOS can be detected correlate significantly (r = 0.75, P < 0.0001). The greater the distance in VF, the greater the distance measured in OCT.CONCLUSIONS. The authors hypothesize that the retinal structure from which the highly reflective layer between the IOS emanates is of critical importance for visual and photoreceptor function. Further research is warranted to determine whether this may be useful as an objective marker of progression of retinal degeneration in patients with RP.