Downregulation of IRS-1 promotes metastasis of head and neck squamous cell carcinoma
Downregulation of IRS-1 promotes metastasis of head and neck squamous cell carcinoma
复制标题
IRS-1的下调促进头颈鳞状细胞癌的转移。
DOI：
10.3892/or.2012.1846
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发表时间：
2012-08-01
期刊：
影响因子：
4.2
通讯作者：
Wang, Xuerong
中科院分区：
文献类型：
--
作者：
Luo, Xuan;Fan, Songqing;Wang, Xuerong
Lymph node metastasis is responsible for the high morbidity of head and neck squamous cell carcinoma (HNSCC). To date, the role of insulin receptor substrate 1 (IRS-1) in tumorigenesis and metastasis of head and neck cancer has not been elucidated. In this study, we found a negative correlation of IRS-1 expression with tumor metastasis both in human tissue samples and in cell lines. Furthermore, we found that knockdown of IRS-1 expression enhanced cell invasive potency and induced EMT in parallel with upregulation of miR-9 expression. We propose that IRS-1 suppresses metastasis of head and neck cancer possibly through miR-9.
