Early motor activity drives spindle bursts in the developing somatosensory cortex
Early motor activity drives spindle bursts in the developing somatosensory cortex
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DOI：
10.1038/nature03132
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发表时间：
2004-12-09
期刊：
影响因子：
64.8
通讯作者：
Buzsáki, G
中科院分区：
文献类型：
--
作者：
Khazipov, R;Sirota, A;Buzsáki, G
感觉运动协调在发育早期就出现了。成熟期的特征是建立躯体定位皮质地图(1，2)，出现远程皮质连接(3)，增强经验依赖性可塑性(4-7)和自发的不协调骨骼运动(8，9)。这些不同的过程如何协作，使体感系统形成身体的三维表示尚不清楚。在视觉系统中，自发网络模式和传入活动之间的相互作用被认为对正常发育至关重要(10，11)。虽然在体外(12-14)的躯体感觉皮层发育过程中已经描述了几种相关神经元活动的内在皮质模式，但体内关键发育期的模式以及生理感觉输入对这些模式的影响尚不清楚。我们在此报道，在新生大鼠体内完整的躯体感觉皮质中，空间受限的纺锤波是第一种也是唯一一种有组织的网络模式。自发性肌肉抽动(8，9)，类似于人类胎儿运动(15，16)的运动模式，以躯体定位的方式选择性地触发定位的纺锤波。我们认为，运动触发的感觉反馈信号和自组织纺锤体振荡之间的相互作用塑造了感觉运动协调所需的皮质连接的形成。
Sensorimotor coordination emerges early in development. The maturation period is characterized by the establishment of somatotopic cortical maps(1,2), the emergence of long-range cortical connections(3), heightened experience-dependent plasticity(4-7) and spontaneous uncoordinated skeletal movement(8,9). How these various processes cooperate to allow the somatosensory system to form a three-dimensional representation of the body is not known. In the visual system, interactions between spontaneous network patterns and afferent activity have been suggested to be vital for normal development(10,11). Although several intrinsic cortical patterns of correlated neuronal activity have been described in developing somatosensory cortex in vitro(12-14), the in vivo patterns in the critical developmental period and the influence of physiological sensory inputs on these patterns remain unknown. We report here that in the intact somatosensory cortex of the newborn rat in vivo, spatially confined spindle bursts represent the first and only organized network pattern. The localized spindles are selectively triggered in a somatotopic manner by spontaneous muscle twitches(8,9), motor patterns analogous to human fetal movements(15,16). We suggest that the interaction between movement-triggered sensory feedback signals and self-organized spindle oscillations shapes the formation of cortical connections required for sensorimotor coordination.