Endothelial biomedicine: Its status as an interdisciplinary field, its progress as a basic science, and its translational bench-to-bedside gap
Endothelial biomedicine: Its status as an interdisciplinary field, its progress as a basic science, and its translational bench-to-bedside gap
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DOI：
10.1080/10623320500192016
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发表时间：
2005-05-01
影响因子：
--
通讯作者：
Aird, WC
中科院分区：
文献类型：
--
作者：
Hwa, C;Sebastian, A;Aird, WC
内皮是所有血管管腔表面的一层内皮细胞，其功能是分布在整个身体内的高度代谢活跃的器官。尽管我们对内皮细胞生物学的理解取得了巨大进步，但对这个器官的认识却很少达到临床实践。本研究旨在记录内皮生物医学中实验室与床边差距的程度和范围，并提供假设来解释这一差距。使用关键词“内皮细胞”和“内皮细胞”进行 PubMed 搜索，产生了 90,000 多篇出版物，在过去十年中呈指数级增长。无日期限制的 Scirus 检索返回的内皮细胞期刊结果并不比上皮细胞少很多。对代表性血管生物学会议的调查显示，与内皮相关的讨论比例很高。美国国立卫生研究院为内皮细胞生物学研究提供的资助数量持续稳步增加。然而，在床边，很少有临床医生考虑内皮的健康。对主要医学教科书的调查显示，“内皮细胞”或“内皮细胞”的索引条目很少。内皮本身不用于检查、触诊、叩诊和/或听诊。没有方便的血液测试可以测量内皮功能。作者建议将内皮生物医学中的实验室与床边差距解释为以下因素的函数：(1) 历史限制；(2) 细胞层的不可见和扩散性质；(3) 系统的复杂性；(4) 其适应性。在实验室与临床之间的差距缩小之前，内皮细胞作为诊断、预防和治疗目标的巨大潜力将在很大程度上尚未开发。
The endothelium, a layer of endothelial cells lining the luminal surface of all blood vessels, functions as a highly metabolically active organ spatially distributed throughout the body. Despite enormous advances in our understanding of endothelial cell biology, little awareness of this organ reaches clinical practice. The present study aims to document the extent and scope of the bench-to-bedside gap in endothelial biomedicine, and to offer hypotheses to explain the gaping chasm. A PubMed search using keywords "endothelial cells" and "endothelium" yielded over 90,000 publications, increasing exponentially over the past decade. A Scirus search without date restriction returned journal results for the endothelium not greatly fewer than for the epithelium. A survey of representative vascular biology meetings revealed a high percentage of talks related to the endothelium. The number of grants awarded by the National Institutes of Health for studies in endothelial cell biology continues to steadily increase. At the bedside, however, few clinicians give consideration to the health of the endothelium. A survey of the major medical textbooks revealed a paucity of index entries for "endothelial cells" or "endothelium." The endothelium does not offer itself for inspection, palpation, percussion, and/or auscultation. No convenient blood tests measure endothelial function. The authors propose to explain the bench-to-bedside gap in endothelial biomedicine as a function of (1) historical constraints, (2) the unseen and diffuse nature of the cell layer, (3) the complexity of the system, and (4) its adaptability. Until the bench-to-bedside gap closes, the enormous potential of the endothelium as a diagnostic, preventive, and therapeutic target will remain largely untapped.