Highly efficient production and simultaneous purification of lactulose via isomerization of lactose through an innovative sustainable anion-extraction process
Highly efficient production and simultaneous purification of lactulose via isomerization of lactose through an innovative sustainable anion-extraction process
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通过创新的可持续阴离子提取工艺，通过乳糖异构化高效生产并同时纯化乳果糖
DOI：
10.1021/acssuschemeng.9b07779
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发表时间：
2020
影响因子：
8.4
通讯作者：
Xiao Hua
中科院分区：
文献类型：
--
作者：
Mingming Wang;Fayin Ye;He Wang;Ruijin Yang;Xiao Hua
传统的乳糖化学异构化为乳果糖面临着不利的热力学限制、显着的副反应和高纯化成本的挑战。在此，提出了一种将提取辅助异构化和同时纯化乳果糖相结合的有效策略。在优化条件下，4-乙烯基苯硼酸（VPBA）有利于乳果糖的选择性提取，可以高选择性（>95%）提取高达80%的乳果糖。提取的乳果糖可以快速（<10 分钟）反提取到酸性 HCl 溶液中，形成浓缩乳果糖流 (∼20 g/L)。通过两阶段汽提过程，乳果糖纯度可显着提高至 99.64%，与 HCl 含量呈函数关系。通过选择性萃取，原位去除由 Na2HPO4+ NaOH 催化的新形成的乳果糖，可以显着提高乳果糖产量并最大限度地减少副产物的形成。所应用的提取辅助异构化策略使乳果糖的收率高达~70%（批量提取模型）和~85%（原位提取模型），并且副产物的收率是有史以来最低的（<5%）。值得注意的是，以VPBA为主的有机相和含催化剂的水相可以很容易地再生和重复使用多次，很好地证明了它们在清洁和可持续工业应用中的可行性。该试验首次验证了使用提取辅助策略可有效同时异构化和分离高纯度乳果糖。
The traditional chemical isomerization of lactose into lactulose faces unfavorable thermodynamic limitations, significant side reactions, and high purification cost challenges. Herein, an efficient strategy for combining extraction-assisted isomerization and simultaneous purification of lactulose is presented. Under optimized conditions, 4-vinylphenylboronic acid (VPBA) favored the selective extraction of lactulose and up to 80% of lactulose can be extracted with a high selectivity (>95%). The extracted lactulose can be rapidly (<10 min) back-extracted into an acidic HCl solution as a concentrated lactulose stream (∼20 g/L). Lactulose purity can significantly be improved to 99.64% through a two-staged stripping process as a function of HCl contents. In situ removal of the newly formed lactulose catalyzed by Na2HPO4+ NaOH through selective extraction could significantly promote lactulose yield and minimize the formation of byproducts. The applied extraction-assisted isomerization strategy enabled the yield of lactulose up to ∼70% (batch-extraction model) and ∼85% (in situ extraction model), with the lowest yield of byproducts (<5%) ever found. Remarkably, the VPBA-dominated organic phase and the catalyst-containing aqueous phase could be easily regenerated and reused multiple times, well proving their feasibility in clean and sustainable industrial applications. This trial validates for the first time the use of the extraction-assisted strategy for an effective simultaneous isomerization and isolation of high-purity lactulose.