Distraction from randomization in diagnostic research
Distraction from randomization in diagnostic research
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DOI：
10.1016/j.annepidem.2005.10.004
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发表时间：
2006-07-01
影响因子：
5.6
通讯作者：
Moons, Karel G. M.
中科院分区：
文献类型：
--
作者：
Biesheuvel, Cornelis J.;Grobbee, Diederick E.;Moons, Karel G. M.
包括诊断测试在内的医疗护理的最终目标是改善患者的预后。因此，它已被广泛提倡，当建立一个测试的诊断准确性，测试对病人的结果的影响，随后必须进行量化。在医学研究中研究患者结局时，使用随机比较是有意义的。在我们看来，随机研究往往是不必要的，以有效地估计诊断测试对患者的结果的影响。横断面诊断研究的结果，结合治疗研究的结果，往往就足够了。
The ultimate goal of medical care, including diagnostic testing, is to improve patient outcome. Accordingly, it has been advocated widely that when establishing a test's diagnostic accuracy, the impact of the test on patient outcome subsequently must be quantified. When studying patient outcome in medical research, the use of randomized comparisons comes into perspective. In our view, randomized studies often are not necessary to validly estimate the effect of the diagnostic test on patient outcome. Results of cross-sectional diagnostic studies, combined with results from therapeutic studies, often will suffice.