Serum IgE levels are associated with coronary artery disease severity
Serum IgE levels are associated with coronary artery disease severity
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血清 IgE 水平与冠状动脉疾病严重程度相关
DOI：
10.1016/j.atherosclerosis.2016.05.020
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发表时间：
2016-08-01
期刊：
影响因子：
5.3
通讯作者：
Shen, Zhujun
中科院分区：
文献类型：
--
作者：
Guo, Xiaoxiao;Yuan, Su;Shen, Zhujun
背景和目标：免疫球蛋白E（IgE）是过敏反应的关键成分，被认为参与了动脉粥样硬化的发展和心肌缺血的发病机制。为探讨血清总IgE水平与冠状动脉粥样硬化程度的关系，对708例冠状动脉造影患者的血清总IgE水平进行了测定。CAD的动脉粥样硬化严重程度通过显示直径狭窄>= 50%的病变血管的数量进行评估，并通过Gensini评分进行量化。CAD患者（N = 562）的血清IgE水平高于非CAD患者（N = 146）[55.90（19.10 - 156.00）vs. 26.90（11.80 - 62.10）KU/L，p = 0.003]。此外，与单支血管疾病患者相比，多支血管疾病（MVD）患者的血清IgE水平显著升高[61.80（23.20 - 159.00）vs. 32.45（14.15 - 94.38）KU/L，p = 0.003]。调整传统心血管危险因素后，高血清IgE水平是MVD风险增加的独立预测因素（OR 1.003; 95%CI 1.001 - 1.004; p = 0.041）。受试者工作特征曲线分析表明，血清IgE水平提高了MVD传统危险因素的预测能力（有和无IgE的曲线下面积：分别为0.734和0.713，p <0.001）。同时，Gensini评分与血清IgE水平四分位数之间存在显著的线性关系（p <0.001）。结论：血清总IgE水平升高与MVD相关，有助于区分CAD的严重程度，而与传统的心血管危险因素无关。(C)2016爱思唯尔爱尔兰有限公司版权所有。
Background and aims: Immunoglobulin E (IgE), a key element of allergic reactions, was considered to be involved in the development of atherosclerosis and the pathogenesis of myocardial ischemia. This study was designed to test whether total serum IgE levels were associated with the atherosclerosis severity of coronary artery disease (CAD).Methods: Total serum IgE concentrations were measured in 708 consecutive patients who were presented to our center for coronary angiography. Atherosclerosis severity of CAD was assessed by the number of diseased vessels showing >= 50% diameter stenosis and quantified by Gensini score.Results: Patients with CAD (N = 562) had higher serum IgE levels than those without CAD (N = 146) [55.90 (19.10-156.00) vs. 26.90 (11.80-62.10) KU/L, p = 0.003]. Furthermore, the serum IgE levels were significantly increased in patients with multivessel disease (MVD) compared to those with single-vessel disease [61.80 (23.20-159.00) vs. 32.45(14.15-94.38) KU/L, p = 0.003]. After adjustment for traditional cardiovascular risk factors, a high serum IgE level was an independent predictor for an increased risk of MVD (OR 1.003; 95% CI 1.001-1.004; p = 0.041). Receiver-operating characteristic curve analysis demonstrated that serum IgE levels improved the predictive capability of traditional risk factors for MVD (area under the curve with and without IgE: 0.734 and 0.713, respectively, p < 0.001). Meanwhile, there was a significant linear relationship between Gensini score and the serum IgE level quartiles (p for linear trend < 0.001).Conclusions: Increased total serum IgE levels are associated with MVD and contribute to discriminating CAD severity independently of traditional cardiovascular risk factors. (C) 2016 Elsevier Ireland Ltd. All rights reserved.