Theta burst stimulation of the human motor cortex
Theta burst stimulation of the human motor cortex
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DOI：
10.1016/j.neuron.2004.12.033
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发表时间：
2005-01-20
期刊：
影响因子：
16.2
通讯作者：
Rothwell, JC
中科院分区：
文献类型：
--
作者：
Huang, YZ;Edwards, MJ;Rothwell, JC
自从发现对神经通路的反复电刺激可以导致海马切片的长期增强以来，已经过去了30年。由于其与学习和记忆等过程的相关性，这项技术在动物模型中产生了大量关于突触可塑性机制的文献。迄今为止，将这些方法转移到人类身上最有希望的方法是重复经颅磁刺激（rTMS），这是一种通过完整的头皮刺激有意识受试者大脑中的神经通路的非侵入性方法。然而，据报道，对突触可塑性的影响通常很弱，个体之间差异很大，而且很少持续超过30分钟。在这里，我们描述了一种非常快速的调节人类运动皮层的方法，使用rTMS，在仅20-190秒的应用期后，对运动皮层的生理和行为产生可控的、一致的、持久的和强大的影响。
It has been 30 years since the discovery that repeated electrical stimulation of neural pathways can lead to long-term potentiation in hippocampal slices. With its relevance to processes such as learning and memory, the technique has produced a vast literature on mechanisms of synaptic plasticity in animal models. To date, the most promising method for transferring these methods to humans is repetitive transcranial magnetic stimulation (rTMS), a noninvasive method of stimulating neural pathways in the brain of conscious subjects through the intact scalp. However, effects on synaptic plasticity reported are often weak, highly variable between individuals, and rarely last longer than 30 min. Here we describe a very rapid method of conditioning the human motor cortex using rTMS that produces a controllable, consistent, long-lasting, and powerful effect on motor cortex physiology and behavior after an application period of only 20-190 s.