Antibodies among men and children to placental-binding Plasmodium falciparum-infected erythrocytes that express var2csa
Antibodies among men and children to placental-binding Plasmodium falciparum-infected erythrocytes that express var2csa
复制标题
DOI：
10.4269/ajtmh.2007.77.22
复制
发表时间：
2007-07-01
影响因子：
3.3
通讯作者：
Marsh, Kevin
中科院分区：
文献类型：
--
作者：
Beeson, James G.;Ndungu, Francis;Marsh, Kevin
在妊娠期间，恶性疟原虫感染的红细胞（IE）的特定变体可以通过var2csa型基因编码的PfEMP 1的表达介导的硫酸软骨素A（CSA）粘附在胎盘中积累。针对这些变体的抗体与保护免受母体疟疾有关。我们评估了肯尼亚、巴布亚新几内亚和马拉维男性以及肯尼亚儿童对两种不同的表达var2csa变体的CSA结合恶性疟原虫分离株的抗体。在每个人群的一些男性和儿童中，特异性IgG水平显著，表明暴露于这些变体并不局限于妊娠。然而，抗体的水平和患病率总体上大大低于暴露的经产妇。IgG结合是特异性的，并不代表非CSA结合IE亚群的抗体，一些血清抑制IE粘附CSA。这些发现对了解疟疾发病机制和免疫具有重要意义，并可能对了解母体疟疾免疫力的获得具有重要意义。
During pregnancy, specific variants of Plasmodium falciparum-infected erythrocytes (IEs) can accumulate in the placenta through adhesion to chondroitin sulfate A (CSA) mediated by expression of PfEMP1 encoded by var2csa-type genes. Antibodies against these variants are associated with protection from maternal malaria. We evaluated antibodies among Kenyan, Papua New Guinean, and Malawian men and Kenyan children against two different CSA-binding P. falciparum isolates expressing var2csa variants. Specific IgG was present at significant levels among some men and children from each population, suggesting exposure to these variants is not exclusive to pregnancy. However, the level and prevalence of antibodies was substantially lower overall than exposed multigravidas. IgG-binding was specific and did not represent antibodies to subpopulations of non-CSA-binding IEs, and some sera inhibited IE adhesion to CSA. These findings have significant implications for understanding malaria pathogenesis and immunity and may be significant for understanding the acquisition of immunity to maternal malaria.