Membrane skeleton in Schmidt-Lanterman incisure in Schwann cells of the peripheral nervous system
Membrane skeleton in Schmidt-Lanterman incisure in Schwann cells of the peripheral nervous system
复制标题
周围神经系统雪旺细胞施密特-兰特曼切口的膜骨架
DOI：
10.1007/978-4-431-54764-8_3
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Ohno S
中科院分区：
文献类型：
--
作者：
Terada N;Saitoh Y;Ohno N;Ohno S
Schmidt–Lanterman incisure (SLI), a truncated cone–shape in a myelin internode, is a specific feature of myelinated nerve fibers in the peripheral nervous system (PNS). In this review, we focus on the membrane skeleton in SLI. First, we describe a membrane skeletal protein, 4.1G, and its relationship to membrane palmitoylated protein 6 (MPP6) and cell adhesion molecule 4 (CADM4), which is analogous to a molecular complex in the erythrocyte membrane skeleton, 4.1R–MPP1–glycophorin C. In 4.1G-deficient nerve fibers, the height of the SLI-truncated cones was reduced compared to that in the wild type. 4.1G was essential for molecular targeting of MPP6 and CADM4 in SLI. Second, we discuss a signal transduction protein, Src, in the SLIs of mouse sciatic nerves, and its phosphorylation states under normal conditions or deletion of 4.1G. Normally, Src is phosphorylated in Y527, but not in Y418. Developmentally, the phosphorylation in Y418 appeared in SLIs of early postnatal mouse sciatic nerves. An MPP6–Src interaction was found, and the phosphorylation of Y418 appeared in 4.1G-deficient nerve fibers. The functional meaning of the Src localization in SLI is discussed. Here, we demonstrate a novel Src–MPP6–4.1G–CADM4 membrane skeletal molecular complex in SLIs, with potential roles in regulation of adhesion and signal transduction in Schwann cells.
