The clinical value of the quantitative detection of four cancer-testis antigen genes in multiple myeloma.
The clinical value of the quantitative detection of four cancer-testis antigen genes in multiple myeloma.
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四种癌睾丸抗原基因定量检测在多发性骨髓瘤中的临床价值
DOI：
10.1186/1476-4598-13-25
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发表时间：
2014-02-05
期刊：
影响因子：
37.3
通讯作者：
Ruan GR
中科院分区：
文献类型：
--
作者：
Zhang Y;Bao L;Lu J;Liu KY;Li JL;Qin YZ;Chen H;Li LD;Kong Y;Shi HX;Lai YY;Liu YR;Jiang B;Chen SS;Huang XJ;Ruan GR
BackgroundCancer-testis (CT) antigen genes might promote the progression of multiple myeloma (MM). CT antigens may act as diagnostic and prognostic markers in MM, but their expression levels and clinical implications in this disease are not fully understood. This study measured the expression levels of four CT antigen genes in Chinese patients with MM and explored their clinical implications.MethodsReal-time quantitative polymerase chain reaction (qPCR) was used to quantify the expression of MAGE-C1/CT7, MAGE-A3, MAGE-C2/CT10 and SSX-2 mRNA in 256 bone marrow samples from 144 MM patients.ResultsIn the newly diagnosed patients, the positive expression rates were 88.5% for MAGE-C1/CT7, 82.1% for MAGE-C2/CT10, 76.9% for MAGE-A3 and 25.6% for SSX-2. The expression levels and the number of co-expressed CT antigens correlated significantly with several clinical indicators, including the percentage of plasma cells infiltrating the bone marrow, abnormal chromosome karyotypes and the clinical course.ConclusionMAGE-C1/CT7, MAGE-A3, MAGE-C2/CT10 and SSX-2 expression levels provide potentially effective clinical indicators for the auxiliary diagnosis and monitoring of treatment efficacy in MM.
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DOI：
10.3324/haematol.2009.014464
发表时间：
2010-05-01
期刊：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
影响因子：
--
作者：
Atanackovic, Djordje;Hildebrandt, York;Kroeger, Nicolaus
通讯作者：
Kroeger, Nicolaus
DOI：
10.1002/hed.21314
发表时间：
2010-09-01
影响因子：
2.9
作者：
Pastorcic-Grgic, Marija;Sarcevic, Bozena;Grgic, Marko
通讯作者：
Grgic, Marko
影响因子：
11.4
作者：
Beillard, E;Pallisgaard, N;Gabert, J
通讯作者：
Gabert, J
影响因子：
11.4
作者：
通讯作者：
--
影响因子：
11.4
作者：
Durie, B. G. M.;Harousseau, J-L;Rajkumar, S. V.
通讯作者：
Rajkumar, S. V.