Possible biotin deficiency in adults receiving long-term total parenteral nutrition.
Possible biotin deficiency in adults receiving long-term total parenteral nutrition.
复制标题
接受长期全胃肠外营养的成人可能缺乏生物素。
DOI：
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发表时间：
1983
影响因子：
7.1
通讯作者：
D. Allardyce
中科院分区：
文献类型：
--
作者：
S. Innis;D. Allardyce
两名长期在家接受全肠外营养的成年患者出现严重脱发。两名患者均接受了广泛的肠道切除，未口服生物素，也未肠胃外接受生物素。每天补充一瓶含有 200 微克生物素的 Berroca-C，可使健康头发逐渐再生。患者现在接受含有生物素的肠胃外溶液，并且没有表现出脱发复发。有人认为，当没有向身体提供预先形成的生物素并且肠道微生物生物合成对这种维生素的贡献受到损害时，成人可能会出现生物素缺乏症。
Two adult patients receiving total parenteral nutrition on a long-term home basis presented with severe loss of hair. Both patients had extensive gut resection, consumed no biotin orally and received no biotin parenterally. Supplementation with Berroca-C, one ampule containing 200 micrograms biotin per day resulted in gradual regrowth of healthy hair. The patients now receive a parenteral solution containing biotin and have shown no recurrence of alopecia. It is suggested that biotin deficiency can occur in the adult when no preformed biotin is provided to the body and the contribution of this vitamin from intestinal microbial biosynthesis is compromised.