Optimal Use of Vaccines for Control of Influenza A Virus in Swine.
Optimal Use of Vaccines for Control of Influenza A Virus in Swine.
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DOI：
10.3390/vaccines3010022
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发表时间：
2015-01-30
期刊：
影响因子：
7.8
通讯作者：
Roth JA
中科院分区：
文献类型：
--
作者：
Sandbulte MR;Spickler AR;Zaabel PK;Roth JA
猪源甲型流感病毒(IAV-S)是北美最重要的猪传染性疾病病原之一。除了IAV-S给养猪业带来经济负担外，IAV-S的人畜共患病潜力有时还会导致严重的公共卫生问题。有佐剂的灭活疫苗在美国已经获得许可20多年了，自体/定制的S疫苗也得到了广泛的使用。接种疫苗会诱导中和抗体，并防止感染非常相似的菌株。然而，鸡传染性法氏囊病病毒S毒株种类繁多且易发生突变，这些疫苗在现场往往效果令人失望。这项科学综述旨在帮助兽医和其他人确定针对特定感染群体的最佳可用的S疫苗。我们描述了鸡传染性支气管炎病毒S的结构和复制、保护性免疫、目前可用的疫苗以及未来有希望的疫苗技术的关键原理。基于从现代诊断和监测项目中收集的信息，我们讨论了优化使用可用S疫苗的策略。改进IAV-S免疫策略，无论是短期还是长期，都将有利于猪的健康和生产力，并有可能降低对公共卫生的风险。
Influenza A virus in swine (IAV-S) is one of the most important infectious disease agents of swine in North America. In addition to the economic burden of IAV-S to the swine industry, the zoonotic potential of IAV-S sometimes leads to serious public health concerns. Adjuvanted, inactivated vaccines have been licensed in the United States for over 20 years, and there is also widespread usage of autogenous/custom IAV-S vaccines. Vaccination induces neutralizing antibodies and protection against infection with very similar strains. However, IAV-S strains are so diverse and prone to mutation that these vaccines often have disappointing efficacy in the field. This scientific review was developed to help veterinarians and others to identify the best available IAV-S vaccine for a particular infected herd. We describe key principles of IAV-S structure and replication, protective immunity, currently available vaccines, and vaccine technologies that show promise for the future. We discuss strategies to optimize the use of available IAV-S vaccines, based on information gathered from modern diagnostics and surveillance programs. Improvements in IAV-S immunization strategies, in both the short term and long term, will benefit swine health and productivity and potentially reduce risks to public health.