VASOPRESSIN RELEASE PRODUCED IN ANAESTHETIZED CATS BY ANTAGONISTS OF γ‐AMINOBUTYRIC ACID AND GLYCINE
VASOPRESSIN RELEASE PRODUCED IN ANAESTHETIZED CATS BY ANTAGONISTS OF γ‐AMINOBUTYRIC ACID AND GLYCINE
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γ-氨基丁酸和甘氨酸拮抗剂在麻醉猫中释放加压素
DOI：
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发表时间：
1978
影响因子：
7.3
通讯作者：
M. Silva
中科院分区：
文献类型：
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作者：
W. Feldberg;M. Silva
1在氯醛糖麻醉的猫上，将中枢兴奋性物质筒箭毒碱、印防己毒素、荷包牡丹碱、来他唑和士的宁通过成对的Perspex环置于脑干暴露的腹侧表面，观察它们对加压素释放和动脉血压的影响。2.在斜方体尾侧6- 9mm处，兴奋性物质释放大量加压素。以前曾用尼古丁从该区域释放加压素。3尼古丁作用下，加压素几乎立即释放，快速耐受迅速发展。随着兴奋性物质的释放逐渐增加，没有快速耐受。当这些物质应用几分钟，释放达到其最大值后相当长的时间，除去，除了与leptazol时，释放减少后立即删除。4.兴奋性物质作用于加压素释放区时对动脉血压影响不大或无影响，但作用于更靠近嘴部的区域时产生强烈的升压反应。5.结论是兴奋性物质释放加压素并升高动脉血压，因为它们是γ-氨基丁酸和/或甘氨酸的拮抗剂，并且许多释放这些氨基酸的抑制性神经元在延髓的腹侧表面形成突触。那些在加压素释放区突触的神经元的生理功能可能是作为加压素释放的制动器，而那些在更靠近嘴部的区域突触的神经元的生理功能是作为动脉血压的制动器。
1 In cats anaesthetized with chloralose, the central excitatory substances, tubocurarine, picrotoxin, bicuculline, leptazol and strychnine, were applied to the exposed ventral surface of the brain stem through paired Perspex rings placed across the medulla and their effects on vasopressin release and arterial blood pressure were examined. 2 The excitatory substances released large amounts of vasopressin when applied to an area 6–9 mm caudal to the trapezoid bodies. From this area vasopressin release was previously obtained with nicotine. 3 With nicotine, the vasopressin release occurred almost instantaneously and tachyphylaxis developed rapidly. With the excitatory substances the release increased gradually and there was no tachyphylaxis. When these substances were applied for several minutes, the release reached its maximum a considerable time after their removal, except with leptazol when release diminished at once after removal. 4 The excitatory substances had little or no effect on arterial blood pressure when applied to the vasopressin releasing area, but produced strong pressor responses when applied to a more rostrally situated area. 5 It is concluded that the excitatory substances release vasopressin and raise arterial blood pressure because they are antagonists of γ‐aminobutyric acid and/or glycine and that numerous inhibitory neurones which release these amino‐acids synapse at the ventral surface of the medulla. The physiological function of those which synapse at the vasopressin releasing area may be to act as a brake on vasopressin release, and of those which synapse at the more rostrally situated area to act as a brake on arterial blood pressure.