Heritability Analysis of Life Span in a Semi-isolated Population Followed Across Four Centuries Reveals the Presence of Pleiotropy Between Life Span and Reproduction
Heritability Analysis of Life Span in a Semi-isolated Population Followed Across Four Centuries Reveals the Presence of Pleiotropy Between Life Span and Reproduction
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DOI：
10.1093/gerona/glq163
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发表时间：
2011-01-01
影响因子：
5.1
通讯作者：
Wjst, Matthias
中科院分区：
文献类型：
--
作者：
Goegele, Martin;Pattaro, Cristian;Wjst, Matthias
虽然已知遗传因素会影响人类的衰老过程，但它们所解释的寿命和寿命变异的比例仍然存在争议。我们评估了遗传寿命的贡献，从三个阿尔卑斯山社区在南蒂罗尔，意大利的历史数据。我们估计了寿命和生存到老年（长寿）的遗传力，并评估了寿命和生殖之间存在共同遗传背景的假设。寿命的遗传力为0.15（SE = 0.02），而寿命的遗传力随着寿命阈值的增加而从0.20增加到0.35。遗传力估计值受共享环境的影响很小，很可能是由于我们研究人群中生活方式和环境因素的同质性。寿命与生育史因素呈正相关，并存在遗传相关。我们的研究表明，人类寿命的遗传一般较低，但考虑到长寿的个体，以及寿命和生殖的共同遗传背景，与衰老的进化理论一致，这种遗传会大幅增加。
Although genetic factors are known to influence the human aging process, the proportion of life span and longevity variation explained by them is still controversial. We evaluated the genetic contribution to life span using historical data from three Alpine communities in South Tyrol, Italy. We estimated the heritability of life span and survival to old age (longevity), and we assessed the hypothesis of a common genetic background between life span and reproduction. The heritability of life span was 0.15 (SE = 0.02), whereas the heritability of longevity increased from 0.20 to 0.35 as the longevity threshold increased. Heritability estimates were little influenced by shared environment, most likely due to the homogeneity of lifestyle and environmental factors in our study population. Life span showed both positive association and genetic correlation with reproductive history factors. Our study demonstrates a general low inheritance of human life span, but which increases substantially when considering long-living individuals, and a common genetic background of life span and reproduction, in agreement with evolutionary theories of aging.