Practice of personalized primary prevention of lifestyle diseases: associated problems and issues in Japan.
Practice of personalized primary prevention of lifestyle diseases: associated problems and issues in Japan.
复制标题
生活方式疾病个性化一级预防的实践：日本的相关问题和问题。
作者：
H. Yamanaka;Keiko Takeda
本文探讨了日本基于个体基因组信息的生活方式疾病个性化一级预防的现状。日本的医疗保健系统和基因检测的监管框架已经被审查，因为它们与这个问题有关。我们认为，日本的诊所和健康检查中心是实施初级预防生活方式疾病措施的适当中心。例如，我们研究了糖尿病并发症和代谢综合征的预测性基因检测程序。根据我们对医生和专家的采访，我们确定了以下因素，这些因素对于有效利用基因检测来预防生活方式疾病至关重要：评估预测性基因检测可信度的制度框架；预测性基因检测的心理影响（阳性和阴性）；对医生和其他卫生专业人员进行生活方式疾病遗传学和与患者有效沟通方面的教育。
This article explores the current situation of personalized primary prevention of lifestyle diseases based on individuals' genome information in Japan. The Japanese healthcare system and regulatory framework of genetic testing have been reviewed because they relate to the issue. From our perspective, clinics and health check-up centers in Japan are appropriate centers for implementing measures for primary prevention of lifestyle diseases. For example, we researched a predictive genetic testing program for diabetic complications and metabolic syndrome. Based on our interviews with physicians and experts, we identified the following factors that are critical to the effective use of genetic testing for primary prevention of lifestyle diseases: an institutional framework for evaluating the credibility of predictive genetic testing; psychological effects (both positive and negative) of predictive genetic testing; and education of physicians and other health professionals in lifestyle disease genetics and effective communication with patients.
DOI：
10.1056/nejmoa0804742
发表时间：
2008-11-20
期刊：
The New England journal of medicine
影响因子：
--
作者：
Meigs JB;Shrader P;Sullivan LM;McAteer JB;Fox CS;Dupuis J;Manning AK;Florez JC;Wilson PW;D'Agostino RB Sr;Cupples LA
通讯作者：
Cupples LA
影响因子：
158.5
作者：
Kathiresan, Sekar;Melander, Olle;Orho-Melander, Marju
通讯作者：
Orho-Melander, Marju