Fitting techniques of cell survival curves in high-dose region for use in stereotactic body radiation therapy
Fitting techniques of cell survival curves in high-dose region for use in stereotactic body radiation therapy
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DOI：
10.1088/0031-9155/54/6/013
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发表时间：
2009-03-01
影响因子：
3.5
通讯作者：
Ahmad, S.
中科院分区：
文献类型：
--
作者：
McKenna, F. W.;Ahmad, S.
立体定向放射治疗 (SBRT) 使用高剂量的放射线来治疗肿瘤。这些高剂量下的细胞存活行为存在争议。我们通过将各种公式与细胞存活数据拟合来研究这个高剂量区域。每个公式的动机都是对细胞生存理论的讨论。检查了十四个细胞系。这些适合各种方程。这些方程包括传统的单次命中多目标和线性二次方程以及最近的提议，例如通用生存曲线（USC）。比较每个拟合的 chi(2)/df 以确定最佳拟合。虽然没有任何公式明显优于所有细胞系，但较新的公式通常比单次命中多目标和线性二次公式提供更好的拟合。我们建议在处理 SBRT 中处理的高剂量区域时，使用本文讨论的更新公式而不是线性二次公式。
Stereotactic body radiation therapy (SBRT) uses high doses of radiation to treat tumors. The cell survival behavior at these high doses is subject to debate. We investigated this high-dose region by fitting a variety of formulas to cell survival data. Each of the formulas is motivated by a discussion of the theory of cell survival. Fourteen cell lines are examined. These are fit to a variety of equations. Among the equations include the traditional single-hit multi-target and linear quadratic as well as recent proposals such as the universal survival curve (USC). The chi(2)/df of each fit is compared to determine the best fit. While no formula is clearly superior for all cell lines, the newer formulas often provide better fits than the single-hit multi-target and linear quadratic. We recommend that the more recent formula discussed herein be used over the linear quadratic in dealing with the high-dose regions dealt with in SBRT.