Graded bidirectional synaptic plasticity is composed of switch-like unitary events
Graded bidirectional synaptic plasticity is composed of switch-like unitary events
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DOI：
10.1073/pnas.0502332102
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发表时间：
2005-07-05
影响因子：
11.1
通讯作者：
Wang, SSH
中科院分区：
文献类型：
--
作者：
O'Connor, DH;Wittenberg, GM;Wang, SSH
生物信息存储事件通常是离散状态之间的快速转换。在神经系统中，由全有或全无事件引发的双向可塑性可能有助于增强记忆存储的健壮性。在这里，我们报告了在CA3-CA1海马区突触，个体增强和抑制可塑性事件是离散的和不同性质的。个体突触从极高和极低强度状态开始。单一可塑性事件要么全有要么全不发生，并在1分钟内驱动两端之间的突触强度。在幼稚的条件下，大约四分之三的突触开始处于低强度状态。这些单一事件的时序可以解释宏观突触可塑性的时间进程。
Biological information storage events are often rapid transitions between discrete states. In neural systems, the initiation of bidirectional plasticity by all-or-none events may help confer robustness on memory storage. Here, we report that at CA3-CA1 hippocampal synapses, individual potentiation and depression plasticity events are discrete and heterogeneous in nature. Individual synapses began from extreme high and low strength states. Unitary plasticity events were all-or-none and drove synaptic strength between extremes in < 1 min. Under naive conditions, approximately three-fourths of synapses began in a low-strength state. The timing of these unitary events can account for the time course of macroscopic synaptic plasticity.