PEPTIC-ULCERATION WITH MARKED EPITHELIAL ATYPIA FOLLOWING HEPATIC ARTERIAL INFUSION CHEMOTHERAPY - A LESION INITIALLY MISINTERPRETED AS CARCINOMA
PEPTIC-ULCERATION WITH MARKED EPITHELIAL ATYPIA FOLLOWING HEPATIC ARTERIAL INFUSION CHEMOTHERAPY - A LESION INITIALLY MISINTERPRETED AS CARCINOMA
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DOI：
10.1097/00000478-198304000-00005
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发表时间：
1983-01-01
影响因子：
5.6
通讯作者：
LAVANWAY, JM
中科院分区：
文献类型：
--
作者：
WEIDNER, N;SMITH, JG;LAVANWAY, JM
消化性溃疡是转移性疾病肝动脉化疗的已知并发症。据报道，一例消化性溃疡伴有明显的上皮异型性，最初被解释为癌，可能本质上是转移性的。随后的部分胃切除术证明病变良性。对来自接受类似治疗的患者的溃疡和非溃疡粘膜的其他胃活检进行的检查也显示出类似的显着非典型变化。上皮异型性和溃疡的病因尚不清楚，但可能与局部增强的化疗细胞毒性或缺血有关。在这种临床情况下，应注意不要将明显的上皮异型性解释为癌。
Peptic ulceration is a known complication of hepatic arterial chemotherapy for metastatic disease. A case is reported of peptic ulceration associated with marked epithelial atypia initially interpreted as carcinoma, probably metastatic in nature. Subsequent partial gastric resection proved the lesion benign. Examination of other gastric biopsies from ulcerated and nonulcerated mucosa from similarly treated patients has revealed similar marked atypical changes. The etiology of the epithelial atypia and ulceration remains unanswered, but is probably related to locally enhanced chemotherapeutic cytotoxicity or ischemia. Care should be taken not to interpret the marked epithelial atypia as carcinoma in this clinical setting.