Impact of in-patient research participation on subsequent heroin use patterns: implications for ethics and public health
Impact of in-patient research participation on subsequent heroin use patterns: implications for ethics and public health
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DOI：
10.1111/j.1360-0443.2011.03664.x
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发表时间：
2012-03-01
期刊：
影响因子：
6
通讯作者：
Comer, Sandra D.
中科院分区：
文献类型：
--
作者：
Roux, Perrine;Tindall, Claudia;Comer, Sandra D.
目标 对药物依赖的研究通常涉及在受控实验室条件下向有经验的吸毒者施用滥用药物。本研究的主要目的是评估参与此类研究是否会改变研究完成后非寻求治疗的阿片类药物依赖志愿者使用海洛因的频率。设计数据来自四项涉及受控阿片类药物给药的住院研究。哥伦比亚大学药物使用研究中心、纽约州精神病学研究所。参与者 六十九名海洛因依赖者志愿者。测量 使用 Wilcoxon 测试对参与者在参与研究之前和之后 1 个月自我报告的海洛因使用情况进行比较。由于许多参与者报告说他们已经停止使用海洛因，因此在研究完成 1 个月后使用逻辑回归来确定海洛因戒断的相关性。结果 101 名参与者进入了实验室研究，69 名参与者完成了研究。与基线[每天 6.8 (+/- 4.2) 袋]相比，参与研究后 1 个月，自我报告的海洛因使用量显着减少 [每天 1.7 (+/- 2.0) 袋]，69 名完成者中 P < 0.001。此外，42% 的完成者在研究完成 1 个月后戒除海洛因。作为非裔美国人，有阿片类药物依赖治疗史、报告基线时较重地使用海洛因以及较长的海洛因使用史与停止使用海洛因相关。结论 参与阿片类药物给药研究不会增加随后的海洛因使用，并且对于某些个体而言，会导致在短期内接受阿片类药物依赖治疗并停止使用海洛因。
Aims Research on drug dependence often involves the administration of drugs of abuse to experienced drug users under controlled laboratory conditions. The primary objective of this study was to assess whether participation in such research alters the frequency of heroin use by non-treatment-seeking opioid-dependent volunteers after study completion. Design Data were examined from four in-patient studies involving controlled opioid administration. Setting Substance Use Research Center at Columbia University, New York State Psychiatric Institute. Participants Sixty-nine heroin-dependent volunteers. Measurements Participants' self-reported heroin use prior to and 1 month after study participation was compared using aWilcoxon test. Because a number of participants reported that they had stopped using heroin, a logistic regression was used to identify correlates of heroin cessation 1 month after study completion. Findings One hundred and one participants entered laboratory studies and 69 completed them. Self-reported heroin use significantly decreased 1 month after study participation [ 1.7 (+/- 2.0) bags per day] compared to baseline [6.8 (+/- 4.2) bags per day], P < 0.001 among the 69 completers. In addition, 42% of the completers were heroin-abstinent 1 month after study completion. Being African American, having a history of opioid dependence treatment, reporting heavier heroin use at baseline and a longer history of heroin usewere correlated with cessation of heroin use. Conclusions Participation in opioid administration studies does not increase subsequent heroin use and for some individuals leads to accessing opioid dependence treatment and cessation of heroin use in the short term.