Sequence comparison of the dopamine receptor D4 Exon III repetitive region in several species of the order Carnivora
Sequence comparison of the dopamine receptor D4 Exon III repetitive region in several species of the order Carnivora
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DOI：
10.1292/jvms.64.747
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发表时间：
2002-08-01
影响因子：
1.2
通讯作者：
Ito, S
中科院分区：
文献类型：
--
作者：
Inoue-Murayama, M;Matsuura, N;Ito, S
先前证明，狗多巴胺受体D4（DRD 4）基因是多态性的重复数和/或位于第三外显子的39-和12-bp序列的顺序。为了检测重复区域是否存在于食肉目的其他物种中，对灰狼、浣熊狗、亚洲黑熊、普通浣熊和家猫的DRD 4基因的同源区域进行了测序。在犬科中，狼具有与狗447 b等位基因相同的序列，并且在浣熊狗中也识别出与狗DRD 4相似的重复序列。另一方面，在熊、浣熊和猫的序列中没有观察到明显的重复结构。
It was previously demonstrated that the dog dopamine receptor D4 (DRD4) gene is polymorphic in terms of the repeat number and/or order of 39- and 12-bp sequences located in the third exon. To examine whether or not the repetitive region is present in other species of the order Carnivora, the homologous region of DRD4 genes were sequenced in the gray wolf, raccoon dog, Asiatic black bear, common raccoon and domestic cat. In the family Canidae, the wolf had an identical sequence to that of the dog 447b allele, and a repetitive sequence similar to the dog DRD4 was also recognized in the raccoon dog. On the other hand, no obvious repeated structure was observed in the sequences of the bear, raccoon and cat.